1-chloro-2-benzoyloxypropane

Base Information

• Chemical Name: 1-chloro-2-benzoyloxypropane
• CAS No.: 36220-92-5
• Molecular Formula: C₁₀H₁₁ClO₂
• Molecular Weight: 198.649
• Mol file: 36220-92-5.mol

Synonyms:1-chloro-2-benzoyloxypropane

Chemical Property of 1-chloro-2-benzoyloxypropane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-chloro-2-benzoyloxypropane

There total 7 articles about 1-chloro-2-benzoyloxypropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

benzoyl chloride (98-88-4) + methyloxirane (75-56-9,16033-71-9) → 1-chloro-2-benzoyloxypropane (36220-92-5)

Guidance literature:

With zinc(II) oxide; In dichloromethane; at 20 ℃; for 0.5h; regioselective reaction;

DOI:10.1002/hc.20529

Reference yield: 79.0%

benzoyl chloride (98-88-4) + 1-Chloro-2-propanol (127-00-4) → 1-chloro-2-benzoyloxypropane (36220-92-5)

Guidance literature:

In pyridine; at 20 ℃; for 2h;

DOI:10.1016/S0957-4166(02)00121-0

Reference yield:

4-methyl-2-phenyl-1,3-dioxolane (2568-25-4) → 1-chloro-2-benzoyloxypropane (36220-92-5) + 1-hydroxyprop-2-yl benzoate (51591-52-7) + 2-chloropropyl benzoate (7022-98-2) + 2-hydroxypropyl benzoate (37086-84-3)

Guidance literature:

With Iodine monochloride; sodium thiosulfate; Yield given. Multistep reaction. Yields of byproduct given; 1.) 1 h, room temperature;

DOI:10.1039/P19810000977

upstream raw materials:

benzoyl chloride

1-Chloro-2-propanol

4-methyl-2-phenyl-1,3-dioxolane

methyloxirane

Downstream raw materials:

2-ethyl-4-methyl-2-phenyl-[1,3]dioxolane

1-chloro-2(S)-hydroxypropane

(R)-(-)-1-chloro-2-propanol

methyloxirane

Refernces

• 1、 Nakamura, Kaoru,Takenaka, Keishi. "The effect of catechin derivatives on the enantioselectivity of lipase-catalyzed hydrolyses of alkynol benzoate esters". . p. 415 - 422. Retrieved 2007/10/03.
• 2、 Hai-Xia, Lin,Liang-Heng, Xu,Nai-Ju, Huang. "A new synthetic method for haloalkyl carboxylic esters from the radical ring cleavage of cyclic acetals with haloform". . p. 303 - 306. Retrieved 2007/10/03.