5-[(1R,2S,3R,4R)-5'-(tert-butyldiphenylsilyloxy)-2',3'-O-isopropylidene-1',4'-dioxypentyl]-2,4-dimethoxypyrimidine

Base Information

Chemical Name:5-[(1R,2S,3R,4R)-5'-(tert-butyldiphenylsilyloxy)-2',3'-O-isopropylidene-1',4'-dioxypentyl]-2,4-dimethoxypyrimidine
CAS No.:1024616-67-8
Molecular Formula:C₃₀H₄₀N₂O₇Si
Molecular Weight:568.742
Hs Code.:

Synonyms:5-[(1R,2S,3R,4R)-5'-(tert-butyldiphenylsilyloxy)-2',3'-O-isopropylidene-1',4'-dioxypentyl]-2,4-dimethoxypyrimidine

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Chemical Property of 5-[(1R,2S,3R,4R)-5'-(tert-butyldiphenylsilyloxy)-2',3'-O-isopropylidene-1',4'-dioxypentyl]-2,4-dimethoxypyrimidine

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Technology Process of 5-[(1R,2S,3R,4R)-5'-(tert-butyldiphenylsilyloxy)-2',3'-O-isopropylidene-1',4'-dioxypentyl]-2,4-dimethoxypyrimidine

There total 2 articles about 5-[(1R,2S,3R,4R)-5'-(tert-butyldiphenylsilyloxy)-2',3'-O-isopropylidene-1',4'-dioxypentyl]-2,4-dimethoxypyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 6-(tert-butyl-diphenyl-silanyloxymethyl)-4-(2,4-dimethoxy-pyrimidin-5-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ol

: 1024616-67-8
5-[(1R,2S,3R,4R)-5'-(tert-butyldiphenylsilyloxy)-2',3'-O-isopropylidene-1',4'-dioxypentyl]-2,4-dimethoxypyrimidine

Guidance literature:: With L-Selectride; zinc(II) chloride; In tetrahydrofuran; diethyl ether; dichloromethane; at -72 - 20 ℃;
DOI:10.1016/j.bmc.2007.11.039

Reference yield:

: (3aR,4R,6R,6aR)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-4-(2,4-dimethoxy-pyrimidin-5-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ol

: (3aR,4S,6R,6aR)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-4-(2,4-dimethoxy-pyrimidin-5-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ol

: 1024616-67-8
5-[(1R,2S,3R,4R)-5'-(tert-butyldiphenylsilyloxy)-2',3'-O-isopropylidene-1',4'-dioxypentyl]-2,4-dimethoxypyrimidine

: 736993-14-9
C₃₀H₄₀N₂O₇Si

Guidance literature:: (3aR,4R,6R,6aR)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-4-(2,4-dimethoxy-pyrimidin-5-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ol; (3aR,4S,6R,6aR)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-4-(2,4-dimethoxy-pyrimidin-5-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ol; With zinc(II) chloride; In diethyl ether; dichloromethane; at -78 ℃; for 0.5h;

With L-Selectride; In tetrahydrofuran; diethyl ether; dichloromethane; at -78 - 20 ℃; for 18.1667h;

With sodium hydroxide; dihydrogen peroxide; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; at 0 - 20 ℃; for 0.25h;

Reference yield: 91.0%

: 1024616-67-8
5-[(1R,2S,3R,4R)-5'-(tert-butyldiphenylsilyloxy)-2',3'-O-isopropylidene-1',4'-dioxypentyl]-2,4-dimethoxypyrimidine

: 736993-15-0
5-[5'-O-(tert-butyldiphenylsilyl)-2',3'-O-isopropylidene-β-ribofuranosyl]-2,4-dimethoxypyrimidine

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 19h;
DOI:10.1016/j.bmc.2007.11.039