1'-benzyl-5-methyl-4,5-dihydro-3H-spiro[1,5-benzoxazepine-2,4'-piperidine]

Base Information

Chemical Name:1'-benzyl-5-methyl-4,5-dihydro-3H-spiro[1,5-benzoxazepine-2,4'-piperidine]
CAS No.:1298034-42-0
Molecular Formula:C₂₁H₂₆N₂O
Molecular Weight:322.45
Hs Code.:

Synonyms:1'-benzyl-5-methyl-4,5-dihydro-3H-spiro[1,5-benzoxazepine-2,4'-piperidine]

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1'-benzyl-5-methyl-4,5-dihydro-3H-spiro[1,5-benzoxazepine-2,4'-piperidine]

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Technology Process of 1'-benzyl-5-methyl-4,5-dihydro-3H-spiro[1,5-benzoxazepine-2,4'-piperidine]

There total 5 articles about 1'-benzyl-5-methyl-4,5-dihydro-3H-spiro[1,5-benzoxazepine-2,4'-piperidine] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 693789-32-1
1'-benzyl-4,5-dihydro-3H-spiro[1,5-benzoxazepine-2,4'-piperidine]

: 1298034-42-0
1'-benzyl-5-methyl-4,5-dihydro-3H-spiro[1,5-benzoxazepine-2,4'-piperidine]

Guidance literature:: With sodium cyanoborohydride; acetic acid; In water; at 0 ℃; for 18h;
DOI:10.1016/j.ejmech.2011.02.002

Reference yield:

: 118-93-4,104809-67-8
o-hydroxyacetophenone

: 1298034-42-0
1'-benzyl-5-methyl-4,5-dihydro-3H-spiro[1,5-benzoxazepine-2,4'-piperidine]

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyrrolidine / ethanol / Reflux

2.1: pyridine; hydroxylamine hydrochloride / ethanol / 22 h / 0 - 70 °C

3.1: diisobutylaluminium hydride / dichloromethane / 4 h / 0 °C

3.2: 0.33 h / 0 °C

3.3: 0 °C / pH > 9

4.1: sodium cyanoborohydride; acetic acid / water / 18 h / 0 °C

With pyrrolidine; pyridine; hydroxylamine hydrochloride; diisobutylaluminium hydride; sodium cyanoborohydride; acetic acid; In ethanol; dichloromethane; water; 3.1: Beckmann rearrangement / 3.2: Beckmann rearrangement / 3.3: Beckmann rearrangement;
DOI:10.1016/j.ejmech.2011.02.002

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 1298034-42-0
1'-benzyl-5-methyl-4,5-dihydro-3H-spiro[1,5-benzoxazepine-2,4'-piperidine]

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyrrolidine / ethanol / Reflux

2.1: pyridine; hydroxylamine hydrochloride / ethanol / 22 h / 0 - 70 °C

3.1: diisobutylaluminium hydride / dichloromethane / 4 h / 0 °C

3.2: 0.33 h / 0 °C

3.3: 0 °C / pH > 9

4.1: sodium cyanoborohydride; acetic acid / water / 18 h / 0 °C

With pyrrolidine; pyridine; hydroxylamine hydrochloride; diisobutylaluminium hydride; sodium cyanoborohydride; acetic acid; In ethanol; dichloromethane; water; 3.1: Beckmann rearrangement / 3.2: Beckmann rearrangement / 3.3: Beckmann rearrangement;
DOI:10.1016/j.ejmech.2011.02.002