1-(4-(benzylamino)-2-(2-methyl-1H-indol-1-yl)-5,6-dihydropyrido[3,4-d]pyrimidin-7(8H)-yl)ethanone

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Chemical Name:1-(4-(benzylamino)-2-(2-methyl-1H-indol-1-yl)-5,6-dihydropyrido[3,4-d]pyrimidin-7(8H)-yl)ethanone
CAS No.:1542704-60-8
Molecular Formula:C₂₅H₂₅N₅O
Molecular Weight:411.506
Hs Code.:

Synonyms:1-(4-(benzylamino)-2-(2-methyl-1H-indol-1-yl)-5,6-dihydropyrido[3,4-d]pyrimidin-7(8H)-yl)ethanone

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Chemical Property of 1-(4-(benzylamino)-2-(2-methyl-1H-indol-1-yl)-5,6-dihydropyrido[3,4-d]pyrimidin-7(8H)-yl)ethanone

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Technology Process of 1-(4-(benzylamino)-2-(2-methyl-1H-indol-1-yl)-5,6-dihydropyrido[3,4-d]pyrimidin-7(8H)-yl)ethanone

There total 8 articles about 1-(4-(benzylamino)-2-(2-methyl-1H-indol-1-yl)-5,6-dihydropyrido[3,4-d]pyrimidin-7(8H)-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1542704-41-5
N-benzyl-2-(2-methyl-1H-indol-1-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-amine

: 108-24-7
acetic anhydride

: 1542704-60-8
1-(4-(benzylamino)-2-(2-methyl-1H-indol-1-yl)-5,6-dihydropyrido[3,4-d]pyrimidin-7(8H)-yl)ethanone

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 3h;

Reference yield:

: 1000578-08-4
2,4-dichloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine

: 1542704-60-8
1-(4-(benzylamino)-2-(2-methyl-1H-indol-1-yl)-5,6-dihydropyrido[3,4-d]pyrimidin-7(8H)-yl)ethanone

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 16 h / 0 - 20 °C

2: acetonitrile / 12 h / 0 - 20 °C

3: potassium tert-butylate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 1,4-dioxane / 3 h / 0 - 80 °C / Inert atmosphere

4: hydrogenchloride / ethyl acetate / 1 h / 20 °C

5: triethylamine / dichloromethane / 3 h / 0 - 20 °C

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium tert-butylate; triethylamine; XPhos; In 1,4-dioxane; dichloromethane; ethyl acetate; acetonitrile;

Reference yield:

: 1059735-34-0
7-benzyl-2,4-dichloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine

: 1542704-60-8
1-(4-(benzylamino)-2-(2-methyl-1H-indol-1-yl)-5,6-dihydropyrido[3,4-d]pyrimidin-7(8H)-yl)ethanone

Guidance literature:: Multi-step reaction with 6 steps

1: carbonochloridic acid 1-chloro-ethyl ester / 1,2-dichloro-ethane / 16.25 h / 0 - 20 °C

2: triethylamine / dichloromethane / 16 h / 0 - 20 °C

3: acetonitrile / 12 h / 0 - 20 °C

4: potassium tert-butylate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 1,4-dioxane / 3 h / 0 - 80 °C / Inert atmosphere

5: hydrogenchloride / ethyl acetate / 1 h / 20 °C

6: triethylamine / dichloromethane / 3 h / 0 - 20 °C

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; carbonochloridic acid 1-chloro-ethyl ester; potassium tert-butylate; triethylamine; XPhos; In 1,4-dioxane; dichloromethane; ethyl acetate; 1,2-dichloro-ethane; acetonitrile;