2,4-bis-benzyloxy-5-N-(toluene-4-sulfonyl)-7-iodopyrrolo-[3,2-d]pyrimidine

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Chemical Name:2,4-bis-benzyloxy-5-N-(toluene-4-sulfonyl)-7-iodopyrrolo-[3,2-d]pyrimidine
CAS No.:1446175-08-1
Molecular Formula:C₂₇H₂₂IN₃O₄S
Molecular Weight:611.46
Hs Code.:

Synonyms:2,4-bis-benzyloxy-5-N-(toluene-4-sulfonyl)-7-iodopyrrolo-[3,2-d]pyrimidine

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Chemical Property of 2,4-bis-benzyloxy-5-N-(toluene-4-sulfonyl)-7-iodopyrrolo-[3,2-d]pyrimidine

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Technology Process of 2,4-bis-benzyloxy-5-N-(toluene-4-sulfonyl)-7-iodopyrrolo-[3,2-d]pyrimidine

There total 2 articles about 2,4-bis-benzyloxy-5-N-(toluene-4-sulfonyl)-7-iodopyrrolo-[3,2-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.6%

: 1446175-04-7
7-iodo-2,4-bis-benzyloxy-5H-pyrrolo[3,2-d]-pyrimidine

: 98-59-9
p-toluenesulfonyl chloride

: 1446175-08-1
2,4-bis-benzyloxy-5-N-(toluene-4-sulfonyl)-7-iodopyrrolo-[3,2-d]pyrimidine

Guidance literature:: 7-iodo-2,4-bis-benzyloxy-5H-pyrrolo[3,2-d]-pyrimidine; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 1h; Inert atmosphere;

p-toluenesulfonyl chloride; In tetrahydrofuran; mineral oil; at 20 ℃; for 0.5h; Inert atmosphere; Cooling with ice;
DOI:10.1021/jo400913k

Reference yield:

: 222631-56-3
2,4-bis-benzyloxy-5H-pyrrolo[3,2-d]pyrimidine

: 1446175-08-1
2,4-bis-benzyloxy-5-N-(toluene-4-sulfonyl)-7-iodopyrrolo-[3,2-d]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-iodo-succinimide / dichloromethane / Inert atmosphere

2.1: sodium hydride / mineral oil; tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

2.2: 0.5 h / 20 °C / Inert atmosphere; Cooling with ice

With N-iodo-succinimide; sodium hydride; In tetrahydrofuran; dichloromethane; mineral oil;
DOI:10.1021/jo400913k