(R)-N-(5-(3-amino-1-phenylpropylcarbamoyl)-2-chlorophenyl)-2-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide hydrochloride

Base Information

Chemical Name:(R)-N-(5-(3-amino-1-phenylpropylcarbamoyl)-2-chlorophenyl)-2-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide hydrochloride
CAS No.:1386980-40-0
Molecular Formula:C₂₅H₂₃ClN₆O₃*ClH
Molecular Weight:527.41
Hs Code.:

Synonyms:(R)-N-(5-(3-amino-1-phenylpropylcarbamoyl)-2-chlorophenyl)-2-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide hydrochloride

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Chemical Property of (R)-N-(5-(3-amino-1-phenylpropylcarbamoyl)-2-chlorophenyl)-2-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide hydrochloride

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Technology Process of (R)-N-(5-(3-amino-1-phenylpropylcarbamoyl)-2-chlorophenyl)-2-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide hydrochloride

There total 11 articles about (R)-N-(5-(3-amino-1-phenylpropylcarbamoyl)-2-chlorophenyl)-2-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.2%

: 1386981-61-8
(R)-tert-butyl 3-(4-chloro-3-(2-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamido)benzamido)-3-phenylpropylcarbamate

: 1386980-40-0
(R)-N-(5-(3-amino-1-phenylpropylcarbamoyl)-2-chlorophenyl)-2-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 2h;

Reference yield:

: 698-29-3
2-methyl-4-amino-5-cyanopyrimidine

: 1386980-40-0
(R)-N-(5-(3-amino-1-phenylpropylcarbamoyl)-2-chlorophenyl)-2-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: hydrogen; sulfuric acid / palladium 10% on activated carbon / water / 1.25 h / 20 °C / 1551.49 - 2585.81 Torr

2: potassium carbonate; triethylamine / N,N-dimethyl-formamide / 85 °C / Inert atmosphere

3: water; lithium hydroxide / methanol / 4 h / 65 °C

4: triethylamine; HATU / N,N-dimethyl-formamide / 5 h

5: water; lithium hydroxide / methanol / 60 - 65 °C

6: triethylamine; HATU / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

7: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

With hydrogenchloride; sulfuric acid; water; hydrogen; potassium carbonate; triethylamine; HATU; lithium hydroxide; palladium 10% on activated carbon; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 5053-63-4
3-amino-1-phenylpropan-1-ol

: 1386980-40-0
(R)-N-(5-(3-amino-1-phenylpropylcarbamoyl)-2-chlorophenyl)-2-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / tetrahydrofuran / 0 - 20 °C

2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C

3: AD column / carbon dioxide; methanol / Resolution of racemate

4: hydrazine / methanol / 2 h / Reflux

5: triethylamine; HATU / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

6: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

With hydrogenchloride; triethylamine; triphenylphosphine; HATU; hydrazine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; methanol; carbon dioxide; N,N-dimethyl-formamide;