2-[2-chloro-4-fluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]phenoxy]acetic acid

Base Information

Chemical Name:2-[2-chloro-4-fluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]phenoxy]acetic acid
CAS No.:1427406-15-2
Molecular Formula:C₂₁H₁₅ClF₃NO₃
Molecular Weight:421.803
Hs Code.:

Synonyms:2-[2-chloro-4-fluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]phenoxy]acetic acid

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Chemical Property of 2-[2-chloro-4-fluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]phenoxy]acetic acid

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Technology Process of 2-[2-chloro-4-fluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]phenoxy]acetic acid

There total 11 articles about 2-[2-chloro-4-fluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]phenoxy]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1427407-26-8
C₂₃H₁₉ClF₃NO₃

: 1427406-15-2
2-[2-chloro-4-fluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]phenoxy]acetic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

: 1214382-15-6
C₁₃H₇ClF₂O

: 1427406-15-2
2-[2-chloro-4-fluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]phenoxy]acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / tetrahydrofuran / 0 - 20 °C

2.1: borane-THF / tetrahydrofuran / 3 h / 0 - 60 °C / Inert atmosphere

3.1: caesium carbonate / acetone / 0.5 h

3.2: 1 h / 20 °C

4.1: lithium hydroxide; water / tetrahydrofuran / 2 h / 20 °C

With borane-THF; water; sodium hydrogencarbonate; caesium carbonate; lithium hydroxide; In tetrahydrofuran; acetone;

Reference yield:

: 2267-25-6
2-chloro-4-fluoro-1-methoxy-benzene

: 1427406-15-2
2-[2-chloro-4-fluoro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]phenoxy]acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: n-butyllithium / tetrahydrofuran / 1.5 h / -65 °C / Inert atmosphere

1.2: 0.67 h / -60 - -20 °C

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

2.2: 0 - 70 °C

3.1: boron tribromide / dichloromethane / 0 - 20 °C / Inert atmosphere

4.1: sodium hydrogencarbonate / tetrahydrofuran / 0 - 20 °C

5.1: borane-THF / tetrahydrofuran / 3 h / 0 - 60 °C / Inert atmosphere

6.1: caesium carbonate / acetone / 0.5 h

6.2: 1 h / 20 °C

7.1: lithium hydroxide; water / tetrahydrofuran / 2 h / 20 °C

With n-butyllithium; borane-THF; oxalyl dichloride; water; boron tribromide; sodium hydrogencarbonate; caesium carbonate; N,N-dimethyl-formamide; lithium hydroxide; In tetrahydrofuran; dichloromethane; acetone;