2267-25-6

Basic information

• Product Name: 2-Chloro-4-fluoroanisole
• Synonyms: 2-Chloro-4-fluoro-1-methoxybenzene, 2-Chloro-4-fluorophenyl methyl ether;2-CHLORO-4-FLUOROANISOLE;2-Chloro-4-fluoroanisole 98%;2-Chloro-4-fluoroanisole98%;2-Chloro-4-fluoro-1-methoxybenzene
• CAS NO: 2267-25-6
• Molecular Formula: C₇H₆ClFO
• Molecular Weight: 160.57
• Product Categories: Anisole;Anisoles, Alkyloxy Compounds & Phenylacetates;Chlorine Compounds;Fluorine Compounds;Ethers;Organic Building Blocks;Oxygen Compounds
• Mol File: 2267-25-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 197-200 °C(lit.)
• Flash Point: 170 °F
• Appearance: Clear colorless to light yellow/Liquid
• Density: 1.29 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.711mmHg at 25°C
• Refractive Index: n20/D 1.519(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-Chloro-4-fluoroanisole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-4-fluoroanisole(2267-25-6)
• EPA Substance Registry System: 2-Chloro-4-fluoroanisole(2267-25-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• RIDADR: 1993
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 2267-25-6(Hazardous Substances Data)

Usage

Chemical Properties

Transparent light yellow liquid

InChI:InChI=1/C7H6ClFO/c1-10-7-3-2-5(9)4-6(7)8/h2-4H,1H3

Upstream product

• 459-60-9 1-fluoro-4-methoxybenzene 
• 1996-41-4 2-chloro-4-fluorophenol 
• 766-51-8 2-Chloroanisole 
• 110-71-4 1,2-dimethoxyethane 
• 445-83-0 4-fluoro-1-methoxy-2-nitrobenzene 
• 1978-39-8 5-fluoro-2-methoxy-aniline 

Downstream Products

• 1996-41-4 2-chloro-4-fluorophenol 
• 909543-27-7 4-fluoro-2-chloro-3-(trimethylsilyl)anisole 

Relevant articles and documents

Fluorinations of unsymmetrical diaryliodonium salts containing: Ortho -sidearms; Influence of sidearm on selectivity

Activated aromatics were reacted with two different fluoroidoane reagents 1 and 2 in the presence of triflic acid to prepare only the para-substituted diaryliodonium salts. With fluoroiodane 1 the unsymmetrical diaryliodonium salts contained an ortho-propan-2-ol sidearm, whereas the alcohol sidearm was eliminated to form an ortho-styrene sidearm in the reaction with fluoroiodane 2. Only the diaryliodonium salts containing a styrene sidearm were fluorinated successfully to deliver para-fluorinated aromatics in good yields.

Iodine(I) reagents in hydrochloric acid-catalyzed oxidative iodination of aromatic compounds by hydrogen peroxide and iodine

Hydrochloric acid activates the oxidative iodination of aromatic compounds with the iodine- hydrogen peroxide system through the formation of an iodine(I) compound as the iodinating reagent. Activation with hydrochloric acid is more powerful than that with sulfuric acid. The formation of dichloroiodic(I) acid (HICl2) with various forms of hydrogen peroxide was followed using UV spectroscopy. The HICl2 was used as the iodinating reagent. In the preparative oxidative iodinaton of various aromatic compounds, hydrochloric acid was used in a catalytic amount and the iodine(I) reagent was formed in situ with 0.5 equiv. hydrogen peroxide and 0.5 equiv. molecular iodine. Two types of reactivity were observed in oxidative iodination with iodine(I) species catalyzed by hydrochloric acid: in the iodination of anisole 1a better yields of iodination were observed with a smaller amount of hydrochloric acid, while on the contrary 4-tert-butyltoluene 1b gave better yields of iodination upon increasing the amount of hydrochloric acid. Reactivity was further manipulated by the choice of the solvent (MeCN, trifluoroethanol, hexafluoro-2-propanol). Copyright

Chlorination of aromatics with trichloroisocyanuric acid (TCICA) in bronsted-acidic imidazolium ionic liquid [BMIM(SO3H)][OTf]: An economical, green protocol for the synthesis of chloroarenes

A survey study on electrophilic chlorination of aromatics with trichloroisocyanuric acid (TCICA) in Bronsted-acidic imidazolium ionic liquid [BMIM(SO3H)][OTf] is reported. The reactions are performed under very mild conditions (at ～50°C) and give good to excellent yields, depending on the substrates. Chemoselectivity for mono- v. dichlorination can be tuned by changing the arene-to-TCICA ratio and the reaction time. The survey study and competitive experiments suggest that triprotonated/protosolvated TCICA is a selective/moderately reactive transfer-chlorination electrophile. Density functional theory was used as guide to obtain further insight into the nature of the chlorination electrophile and the transfer-chlorination step. CSIRO 2007.