Potassium; 4-{2-[2-(4-chloro-phenyl)-imidazo[4,5-b]pyridin-3-yl]-acetylamino}-butyrate

Base Information

Chemical Name:Potassium; 4-{2-[2-(4-chloro-phenyl)-imidazo[4,5-b]pyridin-3-yl]-acetylamino}-butyrate
CAS No.:118698-78-5
Molecular Formula:C₁₈H₁₆ClN₄O₃*K
Molecular Weight:410.901
Hs Code.:

Synonyms:Potassium; 4-{2-[2-(4-chloro-phenyl)-imidazo[4,5-b]pyridin-3-yl]-acetylamino}-butyrate

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Chemical Property of Potassium; 4-{2-[2-(4-chloro-phenyl)-imidazo[4,5-b]pyridin-3-yl]-acetylamino}-butyrate

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Technology Process of Potassium; 4-{2-[2-(4-chloro-phenyl)-imidazo[4,5-b]pyridin-3-yl]-acetylamino}-butyrate

There total 8 articles about Potassium; 4-{2-[2-(4-chloro-phenyl)-imidazo[4,5-b]pyridin-3-yl]-acetylamino}-butyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 135429-03-7
4-[[[2-(4-chlorophenyl)-3H-imidazo[4,5-b]pyridin-3-yl]acetyl]amino]butanoic acid ethyl ester

: 118698-78-5
Potassium; 4-{2-[2-(4-chloro-phenyl)-imidazo[4,5-b]pyridin-3-yl]-acetylamino}-butyrate

Guidance literature:: With potassium hydroxide; In ethanol; for 2h; Heating;
DOI:10.1021/jm00114a007

Reference yield:

: 5470-18-8,34515-82-7
2-Chloro-3-nitropyridine

: 118698-78-5
Potassium; 4-{2-[2-(4-chloro-phenyl)-imidazo[4,5-b]pyridin-3-yl]-acetylamino}-butyrate

Guidance literature:: Multi-step reaction with 8 steps

1: 90 percent / Et₃N / ethanol / 1.75 h / Heating

2: H₂ / 5percent Pd/C / tetrahydrofuran / 1 h / Ambient temperature

3: 87 percent / Et₃N / tetrahydrofuran / Ambient temperature

4: 48 percent / 0.13 h / 210 - 220 °C

5: 58 percent / aq. NaOH / ethanol / 0.75 h / Heating

6: oxalyl chloride, DMF / 5 h / 60 °C

7: tetrahydrofuran / 1 h / Ambient temperature

8: 35 percent / KOH / ethanol / 2 h / Heating

With potassium hydroxide; sodium hydroxide; oxalyl dichloride; hydrogen; triethylamine; N,N-dimethyl-formamide; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00114a007

Reference yield:

: 90559-63-0
N-(3-nitro-2-pyridinyl)glycine ethyl ester

: 118698-78-5
Potassium; 4-{2-[2-(4-chloro-phenyl)-imidazo[4,5-b]pyridin-3-yl]-acetylamino}-butyrate

Guidance literature:: Multi-step reaction with 7 steps

1: H₂ / 5percent Pd/C / tetrahydrofuran / 1 h / Ambient temperature

2: 87 percent / Et₃N / tetrahydrofuran / Ambient temperature

3: 48 percent / 0.13 h / 210 - 220 °C

4: 58 percent / aq. NaOH / ethanol / 0.75 h / Heating

5: oxalyl chloride, DMF / 5 h / 60 °C

6: tetrahydrofuran / 1 h / Ambient temperature

7: 35 percent / KOH / ethanol / 2 h / Heating

With potassium hydroxide; sodium hydroxide; oxalyl dichloride; hydrogen; triethylamine; N,N-dimethyl-formamide; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00114a007