4-[[[2-(4-chlorophenyl)-3H-imidazo[4,5-b]pyridin-3-yl]acetyl]amino]butanoic acid ethyl ester

Base Information

Chemical Name:4-[[[2-(4-chlorophenyl)-3H-imidazo[4,5-b]pyridin-3-yl]acetyl]amino]butanoic acid ethyl ester
CAS No.:135429-03-7
Molecular Formula:C₂₀H₂₁ClN₄O₃
Molecular Weight:400.865
Hs Code.:

Synonyms:4-[[[2-(4-chlorophenyl)-3H-imidazo[4,5-b]pyridin-3-yl]acetyl]amino]butanoic acid ethyl ester

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Chemical Property of 4-[[[2-(4-chlorophenyl)-3H-imidazo[4,5-b]pyridin-3-yl]acetyl]amino]butanoic acid ethyl ester

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Technology Process of 4-[[[2-(4-chlorophenyl)-3H-imidazo[4,5-b]pyridin-3-yl]acetyl]amino]butanoic acid ethyl ester

There total 8 articles about 4-[[[2-(4-chlorophenyl)-3H-imidazo[4,5-b]pyridin-3-yl]acetyl]amino]butanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 6937-16-2
ethyl γ-aminobutyrate hydrochloride

: 118696-03-0
2-(4-chlorophenyl)-3H-imidazo<4,5-b>pyridine-3-acetic acid

: 530-62-1
1,1'-carbonyldiimidazole

: 135429-03-7
4-[[[2-(4-chlorophenyl)-3H-imidazo[4,5-b]pyridin-3-yl]acetyl]amino]butanoic acid ethyl ester

Guidance literature:: With triethylamine; In tetrahydrofuran;

Reference yield:

: 5470-18-8,34515-82-7
2-Chloro-3-nitropyridine

: 135429-03-7
4-[[[2-(4-chlorophenyl)-3H-imidazo[4,5-b]pyridin-3-yl]acetyl]amino]butanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 90 percent / Et₃N / ethanol / 1.75 h / Heating

2: H₂ / 5percent Pd/C / tetrahydrofuran / 1 h / Ambient temperature

3: 87 percent / Et₃N / tetrahydrofuran / Ambient temperature

4: 48 percent / 0.13 h / 210 - 220 °C

5: 58 percent / aq. NaOH / ethanol / 0.75 h / Heating

6: oxalyl chloride, DMF / 5 h / 60 °C

7: tetrahydrofuran / 1 h / Ambient temperature

With sodium hydroxide; oxalyl dichloride; hydrogen; triethylamine; N,N-dimethyl-formamide; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00114a007

Reference yield:

: 90559-63-0
N-(3-nitro-2-pyridinyl)glycine ethyl ester

: 135429-03-7
4-[[[2-(4-chlorophenyl)-3H-imidazo[4,5-b]pyridin-3-yl]acetyl]amino]butanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: H₂ / 5percent Pd/C / tetrahydrofuran / 1 h / Ambient temperature

2: 87 percent / Et₃N / tetrahydrofuran / Ambient temperature

3: 48 percent / 0.13 h / 210 - 220 °C

4: 58 percent / aq. NaOH / ethanol / 0.75 h / Heating

5: oxalyl chloride, DMF / 5 h / 60 °C

6: tetrahydrofuran / 1 h / Ambient temperature

With sodium hydroxide; oxalyl dichloride; hydrogen; triethylamine; N,N-dimethyl-formamide; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00114a007