6-oxo-4-phenyl-1,4,5,6-tetrahydropyridazine-3-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 6-oxo-4-phenyl-1,4,5,6-tetrahydropyridazine-3-carboxylic acid tert-butyl ester
• CAS No.: 434331-84-7
• Molecular Formula: C₁₅H₁₈N₂O₃
• Molecular Weight: 274.32
• Mol file: 434331-84-7.mol

Synonyms:6-oxo-4-phenyl-1,4,5,6-tetrahydropyridazine-3-carboxylic acid tert-butyl ester

Chemical Property of 6-oxo-4-phenyl-1,4,5,6-tetrahydropyridazine-3-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-oxo-4-phenyl-1,4,5,6-tetrahydropyridazine-3-carboxylic acid tert-butyl ester

There total 1 articles about 6-oxo-4-phenyl-1,4,5,6-tetrahydropyridazine-3-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(diphenylmethylene)glycine tert-butyl ester (81477-94-3) + phenylpropynoic acid ethyl ester (2216-94-6) → 6-oxo-4-phenyl-1,4,5,6-tetrahydropyridazine-3-carboxylic acid tert-butyl ester (434331-84-7)

Guidance literature:

N-(diphenylmethylene)glycine tert-butyl ester; phenylpropynoic acid ethyl ester; With potassium tert-butylate; triphenylphosphine; tert-butyl alcohol; In toluene; at 80 ℃; for 24h;

With hydrazine hydrochloride; sodium acetate; In ethanol; for 24h; Further stages.; Heating;

DOI:10.1021/jo0159800

Reference yield: 95.0%

benzyl bromide (100-39-0) + 6-oxo-4-phenyl-1,4,5,6-tetrahydropyridazine-3-carboxylic acid tert-butyl ester (434331-84-7) → 1-benzyl-4-phenyl-6-oxo-1,4,5,6-tetrahydropyridazine-3-carboxylic acid tert-butyl ester (434331-97-2)

Guidance literature:

With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; In acetonitrile; for 5h; Heating;

DOI:10.1021/jo0159800

Reference yield: 90.0%

bromoacetic acid tert-butyl ester (5292-43-3) + 6-oxo-4-phenyl-1,4,5,6-tetrahydropyridazine-3-carboxylic acid tert-butyl ester (434331-84-7) → 1-tert-butoxycarbonylmethyl-4-phenyl-6-oxo-1,4,5,6-tetrahydropyridazine-3-carboxylic acid tert-butyl ester (434331-92-7)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 20h;

DOI:10.1021/jo0159800

upstream raw materials:

N-(diphenylmethylene)glycine tert-butyl ester

phenylpropynoic acid ethyl ester

Downstream raw materials:

1-tert-butoxycarbonylmethyl-4-phenyl-6-oxo-1,4,5,6-tetrahydropyridazine-3-carboxylic acid tert-butyl ester

1-benzyl-4-phenyl-6-oxo-1,4,5,6-tetrahydropyridazine-3-carboxylic acid tert-butyl ester