Technology Process of (S)-(7-cyano-1,2,3,4-tetrahydrocyclopenta[b]indol-2-yl)carbamic acid isopropyl ester
There total 9 articles about (S)-(7-cyano-1,2,3,4-tetrahydrocyclopenta[b]indol-2-yl)carbamic acid isopropyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
zinc(II) formate; zinc;
1,1'-bis-(diphenylphosphino)ferrocene; palladium;
In
ISOPROPYLAMIDE;
at 110 ℃;
Product distribution / selectivity;
Inert atmosphere;
- Guidance literature:
-
((S)-7-Cyano-1,2,3,4-tetrahydro-cyclopenta[b]indol-2-yl)-carbamic acid tert-butyl ester;
With
hydrogenchloride;
In
1,4-dioxane;
at 20 ℃;
for 18h;
isopropyl chloroformate;
With
N-ethyl-N,N-diisopropylamine;
In
dichloromethane; toluene;
at 20 ℃;
for 4h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium carbonate / water; methanol / 26 h / 20 °C
2.1: acetic acid / 5 h / Reflux
3.1: hydrazine hydrate / ethanol; tetrahydrofuran / 22 h / 20 - 55 °C
4.1: sodium hydrogencarbonate / water; tetrahydrofuran / 1 h / 20 °C
5.1: Chiralcel OJ / methanol / Resolution of racemate
6.1: zinc; zinc diacetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 18 h / 100 °C
7.1: hydrogenchloride / 1,4-dioxane / 18 h / 20 °C
7.2: 4 h / 20 °C
With
hydrogenchloride; zinc diacetate; sodium hydrogencarbonate; sodium carbonate; hydrazine hydrate; acetic acid; zinc;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide;
1.1: Michael Condensation;
