(S)-(7-cyano-1,2,3,4-tetrahydrocyclopenta[b]indol-2-yl)carbamic acid isopropyl ester

Base Information

Chemical Name:(S)-(7-cyano-1,2,3,4-tetrahydrocyclopenta[b]indol-2-yl)carbamic acid isopropyl ester
CAS No.:1029691-23-3
Molecular Formula:C₁₆H₁₇N₃O₂
Molecular Weight:283.33
Hs Code.:
Mol file:1029691-23-3.mol

Synonyms:(S)-(7-cyano-1,2,3,4-tetrahydrocyclopenta[b]indol-2-yl)carbamic acid isopropyl ester

Suppliers and Price of (S)-(7-cyano-1,2,3,4-tetrahydrocyclopenta[b]indol-2-yl)carbamic acid isopropyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(S)-(7-Cyano-1,2,3,4-tetrahydrocyclopenta[b]indol-2-yl)carbamicAcidIsopropylEster
100mg
$ 1100.00

Total 1 raw suppliers

Chemical Property of (S)-(7-cyano-1,2,3,4-tetrahydrocyclopenta[b]indol-2-yl)carbamic acid isopropyl ester

Chemical Property:

Boiling Point:505.9±50.0 °C(Predicted)
PKA:12.33±0.20(Predicted)
Density:1.28±0.1 g/cm3(Predicted)

Purity/Quality:: (S)-(7-Cyano-1,2,3,4-tetrahydrocyclopenta[b]indol-2-yl)carbamicAcidIsopropylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses Tetrahydrocyclopenta[b]indole compounds as therapeutic selective androgen receptor modulators.

Technology Process of (S)-(7-cyano-1,2,3,4-tetrahydrocyclopenta[b]indol-2-yl)carbamic acid isopropyl ester

There total 9 articles about (S)-(7-cyano-1,2,3,4-tetrahydrocyclopenta[b]indol-2-yl)carbamic acid isopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 557-21-1
zinc(II) cyanide

: 1307213-09-7
(S)-7-bromo-1,2,3,4-tetrahydro-cyclopenta[b]indol-2-ylamine (R)-2-hydroxy-3-phenylpropionic acid salt

: 1029691-23-3
(S)-(7-cyano-1,2,3,4-tetrahydrocyclopenta[b]indol-2-yl)carbamic acid isopropyl ester

Guidance literature:: With zinc(II) formate; zinc; 1,1'-bis-(diphenylphosphino)ferrocene; palladium; In ISOPROPYLAMIDE; at 110 ℃; Product distribution / selectivity; Inert atmosphere;

Reference yield: 86.0%

: 1029691-25-5
((S)-7-Cyano-1,2,3,4-tetrahydro-cyclopenta[b]indol-2-yl)-carbamic acid tert-butyl ester

: 108-23-6
isopropyl chloroformate

: 1029691-23-3
(S)-(7-cyano-1,2,3,4-tetrahydrocyclopenta[b]indol-2-yl)carbamic acid isopropyl ester

Guidance literature:: ((S)-7-Cyano-1,2,3,4-tetrahydro-cyclopenta[b]indol-2-yl)-carbamic acid tert-butyl ester; With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 18h;

isopropyl chloroformate; With N-ethyl-N,N-diisopropylamine; In dichloromethane; toluene; at 20 ℃; for 4h;

Reference yield:

: 930-30-3
cyclopent-2-enone

: 1029691-23-3
(S)-(7-cyano-1,2,3,4-tetrahydrocyclopenta[b]indol-2-yl)carbamic acid isopropyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium carbonate / water; methanol / 26 h / 20 °C

2.1: acetic acid / 5 h / Reflux

3.1: hydrazine hydrate / ethanol; tetrahydrofuran / 22 h / 20 - 55 °C

4.1: sodium hydrogencarbonate / water; tetrahydrofuran / 1 h / 20 °C

5.1: Chiralcel OJ / methanol / Resolution of racemate

6.1: zinc; zinc diacetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 18 h / 100 °C

7.1: hydrogenchloride / 1,4-dioxane / 18 h / 20 °C

7.2: 4 h / 20 °C

With hydrogenchloride; zinc diacetate; sodium hydrogencarbonate; sodium carbonate; hydrazine hydrate; acetic acid; zinc; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide; 1.1: Michael Condensation;