H-ALPHA-ME-LEU-OH

Base Information

• Chemical Name: H-ALPHA-ME-LEU-OH
• CAS No.: 105743-53-1
• Molecular Formula: C7H15NO2
• Molecular Weight: 145.202
• Hs Code.: 2922499990
• Mol file: 105743-53-1.mol

Synonyms:(S)-2-Methylleucine;2-Methyl-L-leucine;

Chemical Property of H-ALPHA-ME-LEU-OH

Chemical Property:

• Vapor Pressure: 0.0167mmHg at 25°C
• Refractive Index: 1.465
• Boiling Point: 236 °C at 760 mmHg
• PKA: 2.59±0.41(Predicted)
• Flash Point: 96.5 °C
• PSA: 63.32000
• Density: 1.016 g/cm³
• LogP: 1.53480
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99%, ^*data from raw suppliers

H-α-Me-Leu-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of H-ALPHA-ME-LEU-OH

There total 9 articles about H-ALPHA-ME-LEU-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

C15H19NO4 → (S)-2-amino-2,4-dimethylpentanoic acid (105743-53-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 30 ℃; for 6h; Temperature; Large scale;

Reference yield: 97.6%

α-methylleucine amide (113509-60-7) → (S)-2-amino-2,4-dimethylpentanoic acid (105743-53-1) + D-α-methylleucine amide (113565-54-1)

Guidance literature:

With water; at 37 ℃; for 72h; aminopeptidase from Mycobacterium neoaurum ATCC 25795;

DOI:10.1021/jo00243a049

Reference yield: 83.0%

(3S,5aR,6aS,7aS)-5,5a,6,6a,7,7a-hexahydro-3-isobutyl-3,6,6,7a-tetramethylbicyclo[4.1.0]hept-1(6)eno[3,4-b][1,4]oxazin-2(3H)-one (1266681-15-5) → (S)-2-amino-2,4-dimethylpentanoic acid (105743-53-1)

Guidance literature:

(3S,5aR,6aS,7aS)-5,5a,6,6a,7,7a-hexahydro-3-isobutyl-3,6,6,7a-tetramethylbicyclo[4.1.0]hept-1⁽⁶⁾eno[3,4-b][1,4]oxazin-2(3H)-one; With cesium hydroxide; water; at 70 ℃; for 3h;

With hydrogenchloride; In water;

DOI:10.1021/jo1022537

upstream raw materials:

(3S,9bR)-3-Isobutyl-3-methyl-9bH-1,5-dioxa-3a-aza-cyclopenta[a]naphthalene-2,4-dione

α-methylleucine amide

(3S,5aR,6aS,7aS)-5,5a,6,6a,7,7a-hexahydro-3-isobutyl-3,6,6,7a-tetramethylbicyclo[4.1.0]hept-1⁽⁶⁾eno[3,4-b][1,4]oxazin-2(3H)-one

N-benzylidene<(S)-1-t-butoxycarbonyl-3-methyl>butylamine

Downstream raw materials:

(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2,4-dimethylpentanoic acid

2-({[(4-bromophenyl)amino]carbonyl}amino)-2,4-dimethylpentanoic acid

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