FMOC-ALPHA-ME-LEU-OH

Base Information

• Chemical Name: FMOC-ALPHA-ME-LEU-OH
• CAS No.: 312624-65-0
• Molecular Formula: C₂₂H₂₅NO₄
• Molecular Weight: 367.445
• Hs Code.: 29225090
• Mol file: 312624-65-0.mol

Synonyms:FMOC-ALPHA-ME-LEU-OH;Fmoc-a-Me-Leu-OH

Chemical Property of FMOC-ALPHA-ME-LEU-OH

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.578
• Boiling Point: 562.652°C at 760 mmHg
• PKA: 3.95±0.41(Predicted)
• Flash Point: 294.082°C
• PSA: 75.63000
• Density: 1.19g/cm³
• LogP: 4.80540
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

≥98%, ^*data from raw suppliers

Fmoc-alpha-Me-L-Leucine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): O,Xn,N
• Hazard Codes: O,Xn,N
• Statements: 8-22-50/53
• Safety Statements: 60-61

MSDS Files:

Useful:

Technology Process of FMOC-ALPHA-ME-LEU-OH

There total 3 articles about FMOC-ALPHA-ME-LEU-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

C32H35N3NiO3 + N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) → (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2,4-dimethylpentanoic acid (312624-65-0)

Guidance literature:

C₃₂H₃₅N₃NiO₃; With hydrogenchloride; In methanol; at 70 ℃; for 0.75h;

With sodium carbonate; In water; at 20 ℃; for 0.5h;

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide; In water; acetone; at 0 - 20 ℃; for 22h;

DOI:10.1021/acs.jmedchem.7b00723

Reference yield: 60.0%

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) + (S)-2-amino-2,4-dimethylpentanoic acid (105743-53-1) → (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2,4-dimethylpentanoic acid (312624-65-0)

Guidance literature:

With sodium hydroxide; In water; acetone; at 30 ℃; for 12h; pH=9.5; pH-value; Large scale;

Reference yield:

C22H23NO4 (865468-88-8) → (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2,4-dimethylpentanoic acid (312624-65-0)

Guidance literature:

Multi-step reaction with 3 steps

1: lithium hydroxide; water / tetrahydrofuran / 8 h / 25 °C / Cooling with ice; Large scale

2: palladium 10% on activated carbon; hydrogen / methanol / 6 h / 30 °C / Large scale

3: sodium hydroxide / acetone; water / 12 h / 30 °C / pH 9.5 / Large scale

With palladium 10% on activated carbon; water; hydrogen; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; methanol; water; acetone;

upstream raw materials:

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

(S)-2-amino-2,4-dimethylpentanoic acid

C₂₂H₂₃NO₄

Refernces

• 1、 -. "Synthetic method of (2S)-2-N-fluorene methoxycarbonyl amino-2,4-dimethyl valerate". Paragraph 0010; 0011; 0012. . Retrieved 2019/03/08.