(4aS,5R)-5-(2,5-dimethoxyphenyl)-1,1-dimethyl-3,4,4a,5,7,8-hexahydro-1H-benzo[7]annulen-6(2H)-one

Base Information

Chemical Name:(4aS,5R)-5-(2,5-dimethoxyphenyl)-1,1-dimethyl-3,4,4a,5,7,8-hexahydro-1H-benzo[7]annulen-6(2H)-one
CAS No.:1161984-43-5
Molecular Formula:C₂₁H₂₈O₃
Molecular Weight:328.452
Hs Code.:

Synonyms:(4aS,5R)-5-(2,5-dimethoxyphenyl)-1,1-dimethyl-3,4,4a,5,7,8-hexahydro-1H-benzo[7]annulen-6(2H)-one

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Chemical Property of (4aS,5R)-5-(2,5-dimethoxyphenyl)-1,1-dimethyl-3,4,4a,5,7,8-hexahydro-1H-benzo[7]annulen-6(2H)-one

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Technology Process of (4aS,5R)-5-(2,5-dimethoxyphenyl)-1,1-dimethyl-3,4,4a,5,7,8-hexahydro-1H-benzo[7]annulen-6(2H)-one

There total 1 articles about (4aS,5R)-5-(2,5-dimethoxyphenyl)-1,1-dimethyl-3,4,4a,5,7,8-hexahydro-1H-benzo[7]annulen-6(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1161984-42-4
(R)-5-(2,5-dimethoxyphenyl)-1-(6,6-dimethylcyclohexenyl)-4-pentyn-1-ol

: 1161984-43-5
(4aS,5R)-5-(2,5-dimethoxyphenyl)-1,1-dimethyl-3,4,4a,5,7,8-hexahydro-1H-benzo[7]annulen-6(2H)-one

: 5-(2,5-dimethoxyphenyl)-1,1-dimethyl-3,4,4a,5,7,8-hexahydro-1H-benzo[7]annulen-6(2H)-one

Guidance literature:: With methyllithium; In diethyl ether; Phenetole; at 210 ℃; for 1h; optical yield given as %ee; Microwave irradiation; Inert atmosphere;
DOI:10.1021/ol900967j

Reference yield: 85.0%

: 1161984-43-5
(4aS,5R)-5-(2,5-dimethoxyphenyl)-1,1-dimethyl-3,4,4a,5,7,8-hexahydro-1H-benzo[7]annulen-6(2H)-one

: 74-88-4
methyl iodide

: 1161984-02-6
(4aS,5R,7S)-5-(2,5-dimethoxyphenyl)-1,1,7-trimethyl-3,4,4a,5,7,8-hexahydro-1H-benzo[7]annulen-6(2H)-one

Guidance literature:: (4aS,5R)-5-(2,5-dimethoxyphenyl)-1,1-dimethyl-3,4,4a,5,7,8-hexahydro-1H-benzo[7]annulen-6(2H)-one; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.5h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; at -60 ℃; for 3h; stereospecific reaction; Inert atmosphere;
DOI:10.1021/ol900967j