methyl 4-(benzyloxy)-2,2-dimethyl-3-(trimethylsiloxy)-3-butenoate

Base Information

• Chemical Name: methyl 4-(benzyloxy)-2,2-dimethyl-3-(trimethylsiloxy)-3-butenoate
• CAS No.: 862594-56-7
• Molecular Formula: C₁₇H₂₆O₄Si
• Molecular Weight: 322.477
• Mol file: 862594-56-7.mol

Synonyms:methyl 4-(benzyloxy)-2,2-dimethyl-3-(trimethylsiloxy)-3-butenoate

Chemical Property of methyl 4-(benzyloxy)-2,2-dimethyl-3-(trimethylsiloxy)-3-butenoate

Chemical Property:

Purity/Quality:

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Technology Process of methyl 4-(benzyloxy)-2,2-dimethyl-3-(trimethylsiloxy)-3-butenoate

There total 1 articles about methyl 4-(benzyloxy)-2,2-dimethyl-3-(trimethylsiloxy)-3-butenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

1-methoxy-2-methyl-1-trimethylsiloxy-1-propene (31469-15-5) + methyl 2-(benzyloxy)acetate (31600-43-8) → methyl 4-(benzyloxy)-2,2-dimethyl-3-(trimethylsiloxy)-3-butenoate (862594-56-7)

Guidance literature:

With sodium hydroxide; In N,N-dimethyl-formamide; at 20 - 25 ℃; for 1h; optical yield given as %de; Inert atmosphere;

DOI:10.1016/j.tet.2009.02.084

Reference yield:

methyl 4-(benzyloxy)-2,2-dimethyl-3-(trimethylsiloxy)-3-butenoate (862594-56-7) + benzaldehyde (100-52-7) → methyl 4-(benzyloxy)-5-hydroxy-2,2-dimethyl-3-oxo-5-phenylpentanoate + methyl 4-(benzyloxy)-5-hydroxy-2,2-dimethyl-3-oxo-5-phenylpentanoate

Guidance literature:

methyl 4-(benzyloxy)-2,2-dimethyl-3-(trimethylsiloxy)-3-butenoate; benzaldehyde; With titanium tetrachloride; In dichloromethane; at -45 ℃; for 1h; Inert atmosphere;

With water; In dichloromethane; optical yield given as %de; stereoselective reaction; Inert atmosphere;

DOI:10.1016/j.tet.2009.02.084

upstream raw materials:

1-methoxy-2-methyl-1-trimethylsiloxy-1-propene

methyl 2-(benzyloxy)acetate