(S,Z)-3-(4-chlorophenyl)-4-(1-(4-chlorophenyl)propylidene)-3-ethyloxetan-2-one

Base Information

• Chemical Name: (S,Z)-3-(4-chlorophenyl)-4-(1-(4-chlorophenyl)propylidene)-3-ethyloxetan-2-one
• CAS No.: 1148000-93-4
• Molecular Formula: C₂₀H₁₈Cl₂O₂
• Molecular Weight: 361.268
• Mol file: 1148000-93-4.mol

Synonyms:(S,Z)-3-(4-chlorophenyl)-4-(1-(4-chlorophenyl)propylidene)-3-ethyloxetan-2-one

Chemical Property of (S,Z)-3-(4-chlorophenyl)-4-(1-(4-chlorophenyl)propylidene)-3-ethyloxetan-2-one

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of (S,Z)-3-(4-chlorophenyl)-4-(1-(4-chlorophenyl)propylidene)-3-ethyloxetan-2-one

There total 1 articles about (S,Z)-3-(4-chlorophenyl)-4-(1-(4-chlorophenyl)propylidene)-3-ethyloxetan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

ethyl(p-chlorophenyl)ketene → (S,Z)-3-(4-chlorophenyl)-4-(1-(4-chlorophenyl)propylidene)-3-ethyloxetan-2-one (1148000-93-4)

Guidance literature:

With BF₄^(1-)*C₃₄H₂₂F₁₂N₃O₂⁽¹⁺⁾; caesium carbonate; In tetrahydrofuran; at 20 ℃; for 2h; optical yield given as %ee; enantioselective reaction;

DOI:10.1002/adsc.200800532

Reference yield: 85.4%

(S,Z)-3-(4-chlorophenyl)-4-(1-(4-chlorophenyl)propylidene)-3-ethyloxetan-2-one (1148000-93-4) → (3R,5R)-3,5-bis(4-chlorophenyl)-3-(hydroxymethyl)heptan-4-one (1148001-01-7)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 0.5h; optical yield given as %ee;

DOI:10.1002/adsc.200800532

Downstream raw materials:

(3R,5R)-3,5-bis(4-chlorophenyl)-3-(hydroxymethyl)heptan-4-one