(6S)-6-[[tert-ButyldiMethylsilyloxy]-1,3,4,5,6,7-hexahydro-1-[(E)-[(1R,3aS,7aR)-octahydro-1-[(1S)-2-iodo-1-Methylethyl]-7a-Methyl-4H-inden-4-ylidene]Methyl]benzo[c]thiophene 2,2-Dioxide

Base Information

Chemical Name:(6S)-6-[[tert-ButyldiMethylsilyloxy]-1,3,4,5,6,7-hexahydro-1-[(E)-[(1R,3aS,7aR)-octahydro-1-[(1S)-2-iodo-1-Methylethyl]-7a-Methyl-4H-inden-4-ylidene]Methyl]benzo[c]thiophene 2,2-Dioxide
CAS No.:344798-32-9
Molecular Formula:C₂₈H₄₇IO₃SSi
Molecular Weight:618.735
Hs Code.:

(6S)-6-[[tert-ButyldiMethylsilyloxy]-1,3,4,5,6,7-hexahydro-1-[(E)-[(1R,3aS,7aR)-octahydro-1-[(1S)-2-iodo-1-Methylethyl]-7a-Methyl-4H-inden-4-ylidene]Methyl]benzo[c]thiophene 2,2-Dioxide

Synonyms:3(S)-<(tert-butyldimethylsilyl)oxy>-20(S)-(iodomethyl)-9,10-secopregna-5(Z),7(E),10(19)-triene SO2 adduct

Suppliers and Price of (6S)-6-[[tert-ButyldiMethylsilyloxy]-1,3,4,5,6,7-hexahydro-1-[(E)-[(1R,3aS,7aR)-octahydro-1-[(1S)-2-iodo-1-Methylethyl]-7a-Methyl-4H-inden-4-ylidene]Methyl]benzo[c]thiophene 2,2-Dioxide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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TRC
(6S)-6-[[tert-Butyldimethylsilyloxy]-1,3,4,5,6,7-hexahydro-1-[(E)-[(1R,3aS,7aR)-octahydro-1-[(1S)-2-iodo-1-methylethyl]-7a-methyl-4H-inden-4-ylidene]methyl]benzo[c]thiophene2,2-Dioxide
50mg
$ 275.00

Total 1 raw suppliers

Chemical Property of (6S)-6-[[tert-ButyldiMethylsilyloxy]-1,3,4,5,6,7-hexahydro-1-[(E)-[(1R,3aS,7aR)-octahydro-1-[(1S)-2-iodo-1-Methylethyl]-7a-Methyl-4H-inden-4-ylidene]Methyl]benzo[c]thiophene 2,2-Dioxide

Chemical Property:

Purity/Quality:: (6S)-6-[[tert-Butyldimethylsilyloxy]-1,3,4,5,6,7-hexahydro-1-[(E)-[(1R,3aS,7aR)-octahydro-1-[(1S)-2-iodo-1-methylethyl]-7a-methyl-4H-inden-4-ylidene]methyl]benzo[c]thiophene2,2-Dioxide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses (6S)-6-[[tert-Butyldimethylsilyloxy]-1,3,4,5,6,7-hexahydro-1-[(E)-[(1R,3aS,7aR)-octahydro-1-[(1S)-2-iodo-1-methylethyl]-7a-methyl-4H-inden-4-ylidene]methyl]benzo[c]thiophene 2,2-Dioxide is an intermediate in the synthesis of Secalciferol (S211500), metabolite of Vitamin D, a possible anti-inflammatory steroid.

Technology Process of (6S)-6-[[tert-ButyldiMethylsilyloxy]-1,3,4,5,6,7-hexahydro-1-[(E)-[(1R,3aS,7aR)-octahydro-1-[(1S)-2-iodo-1-Methylethyl]-7a-Methyl-4H-inden-4-ylidene]Methyl]benzo[c]thiophene 2,2-Dioxide

There total 7 articles about (6S)-6-[[tert-ButyldiMethylsilyloxy]-1,3,4,5,6,7-hexahydro-1-[(E)-[(1R,3aS,7aR)-octahydro-1-[(1S)-2-iodo-1-Methylethyl]-7a-Methyl-4H-inden-4-ylidene]Methyl]benzo[c]thiophene 2,2-Dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 344798-31-8
3(S)-<(tert-butyldimethylsilyl)oxy>-20(S)-(hydroxymethyl)-9,10-secopregna-5(Z),7(E),10(19)-triene SO2 adduct

: 344798-32-9
3(S)-<(tert-butyldimethylsilyl)oxy>-20(S)-(iodomethyl)-9,10-secopregna-5(Z),7(E),10(19)-triene SO2 adduct

Guidance literature:: With 1H-imidazole; iodine; triphenylphosphine; In dichloromethane; 1.) 5 deg C, 0.5 h, 2.) room temperature, 2.0 h;
DOI:10.1021/jo00125a051

Reference yield:

: 170081-43-3,251445-16-6
SO2-adduct of 3(S)-<(tert-butyldimethylsilyl)oxy>-9,10-secoergosta-5,7(E),10(19),22(E)-tetraene

: 344798-32-9
3(S)-<(tert-butyldimethylsilyl)oxy>-20(S)-(iodomethyl)-9,10-secopregna-5(Z),7(E),10(19)-triene SO2 adduct

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) O₃, 2.) NaBH₄ / 1.) CH₂Cl₂, MeOH, -10 deg C, 2.) room temperature, 2 h

2: 71 percent / I₂, PPh₃, imidazole / CH₂Cl₂ / 1.) 5 deg C, 0.5 h, 2.) room temperature, 2.0 h

With 1H-imidazole; sodium tetrahydroborate; iodine; ozone; triphenylphosphine; In dichloromethane;
DOI:10.1021/jo00125a051

Reference yield:

: 50-14-6
Calciferol

: 344798-32-9
3(S)-<(tert-butyldimethylsilyl)oxy>-20(S)-(iodomethyl)-9,10-secopregna-5(Z),7(E),10(19)-triene SO2 adduct

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) SO₂

2: 1.) O₃, 2.) NaBH₄ / 1.) CH₂Cl₂, MeOH, -10 deg C, 2.) room temperature, 2 h

3: 71 percent / I₂, PPh₃, imidazole / CH₂Cl₂ / 1.) 5 deg C, 0.5 h, 2.) room temperature, 2.0 h

With 1H-imidazole; sodium tetrahydroborate; sulfur dioxide; iodine; ozone; triphenylphosphine; In dichloromethane;
DOI:10.1021/jo00125a051