methyl 2-(((5-(aminomethyl)-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-4H-1,2,4-triazol-3-yl)methyl)(methyl)amino)acetate

Base Information

Chemical Name:methyl 2-(((5-(aminomethyl)-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-4H-1,2,4-triazol-3-yl)methyl)(methyl)amino)acetate
CAS No.:1417528-49-4
Molecular Formula:C₂₂H₂₄F₃N₅O₂
Molecular Weight:447.46
Hs Code.:

Synonyms:methyl 2-(((5-(aminomethyl)-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-4H-1,2,4-triazol-3-yl)methyl)(methyl)amino)acetate

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Chemical Property of methyl 2-(((5-(aminomethyl)-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-4H-1,2,4-triazol-3-yl)methyl)(methyl)amino)acetate

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Technology Process of methyl 2-(((5-(aminomethyl)-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-4H-1,2,4-triazol-3-yl)methyl)(methyl)amino)acetate

There total 9 articles about methyl 2-(((5-(aminomethyl)-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-4H-1,2,4-triazol-3-yl)methyl)(methyl)amino)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1417528-48-3
methyl 2-(((5-(azidomethyl)-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-4H-1,2,4-triazol-3-yl)methyl)(methyl)amino)acetate

: 1417528-49-4
methyl 2-(((5-(aminomethyl)-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-4H-1,2,4-triazol-3-yl)methyl)(methyl)amino)acetate

Guidance literature:: With water; triphenylphosphine; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 3959-07-7
4-Bromobenzylamine

: 1417528-49-4
methyl 2-(((5-(aminomethyl)-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-4H-1,2,4-triazol-3-yl)methyl)(methyl)amino)acetate

Guidance literature:: Multi-step reaction with 9 steps

1.1: triethylamine / tetrahydrofuran / 1.5 h / 20 °C / Cooling with ice

1.2: 1 h / Cooling with ice

2.1: ethanol / 2 h / Reflux

2.2: 1 h / Reflux

3.1: acetic acid; dihydrogen peroxide / water; dichloromethane / 1.5 h / 20 - 35 °C

4.1: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 18 h / Inert atmosphere; Reflux

5.1: N,N-dimethyl-formamide; thionyl chloride / dichloromethane / 2 h / 20 °C / Cooling with ice

6.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 70 - 80 °C

7.1: 5 h / Reflux

8.1: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 3 h / Inert atmosphere; Reflux

9.1: triphenylphosphine; water / tetrahydrofuran / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; diphenyl phosphoryl azide; water; dihydrogen peroxide; caesium carbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; acetonitrile;

Reference yield:

: 2076-56-4
4-bromobenzyl isothiocyanate

: 1417528-49-4
methyl 2-(((5-(aminomethyl)-4-((4'-(trifluoromethyl)biphenyl-4-yl)methyl)-4H-1,2,4-triazol-3-yl)methyl)(methyl)amino)acetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: ethanol / 2 h / Reflux

1.2: 1 h / Reflux

2.1: acetic acid; dihydrogen peroxide / water; dichloromethane / 1.5 h / 20 - 35 °C

3.1: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 18 h / Inert atmosphere; Reflux

4.1: N,N-dimethyl-formamide; thionyl chloride / dichloromethane / 2 h / 20 °C / Cooling with ice

5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 70 - 80 °C

6.1: 5 h / Reflux

7.1: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 3 h / Inert atmosphere; Reflux

8.1: triphenylphosphine; water / tetrahydrofuran / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; diphenyl phosphoryl azide; water; dihydrogen peroxide; caesium carbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; acetonitrile;