Isopropyl-carbamic acid 5-(4-fluoro-phenyl)-7-isopropylcarbamoyloxymethyl-2,3-dihydro-pyrrolo[2,1-b]thiazol-6-ylmethyl ester

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Chemical Name:Isopropyl-carbamic acid 5-(4-fluoro-phenyl)-7-isopropylcarbamoyloxymethyl-2,3-dihydro-pyrrolo[2,1-b]thiazol-6-ylmethyl ester
CAS No.:114199-37-0
Molecular Formula:C₂₂H₂₈FN₃O₄S
Molecular Weight:449.546
Hs Code.:

Synonyms:Isopropyl-carbamic acid 5-(4-fluoro-phenyl)-7-isopropylcarbamoyloxymethyl-2,3-dihydro-pyrrolo[2,1-b]thiazol-6-ylmethyl ester

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Chemical Property of Isopropyl-carbamic acid 5-(4-fluoro-phenyl)-7-isopropylcarbamoyloxymethyl-2,3-dihydro-pyrrolo[2,1-b]thiazol-6-ylmethyl ester

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Technology Process of Isopropyl-carbamic acid 5-(4-fluoro-phenyl)-7-isopropylcarbamoyloxymethyl-2,3-dihydro-pyrrolo[2,1-b]thiazol-6-ylmethyl ester

There total 3 articles about Isopropyl-carbamic acid 5-(4-fluoro-phenyl)-7-isopropylcarbamoyloxymethyl-2,3-dihydro-pyrrolo[2,1-b]thiazol-6-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 114199-33-6
5-(4-fluorophenyl)-2,3-dihydropyrrolo<2,1-b>thiazole-6,7-dimethanol

: 1795-48-8
Isopropyl isocyanate

: 114199-37-0
Isopropyl-carbamic acid 5-(4-fluoro-phenyl)-7-isopropylcarbamoyloxymethyl-2,3-dihydro-pyrrolo[2,1-b]thiazol-6-ylmethyl ester

Guidance literature:: With triethylamine; In dichloromethane; Heating;
DOI:10.1021/jm00402a030

Reference yield:

: 114199-23-4
3-(4-Fluorobenzoyl)thiazolidinecarboxylic acid

: 114199-37-0
Isopropyl-carbamic acid 5-(4-fluoro-phenyl)-7-isopropylcarbamoyloxymethyl-2,3-dihydro-pyrrolo[2,1-b]thiazol-6-ylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / Ac₂O / Heating

2: 97 percent / LiAlH₄ / CH₂Cl₂; diethyl ether / 1 h / Heating

3: 95 percent / Et₃N / CH₂Cl₂ / Heating

With lithium aluminium tetrahydride; acetic anhydride; triethylamine; In diethyl ether; dichloromethane;
DOI:10.1021/jm00402a030

Reference yield:

: 114199-28-9
5-(4-Fluoro-phenyl)-2,3-dihydro-pyrrolo[2,1-b]thiazole-6,7-dicarboxylic acid dimethyl ester

: 114199-37-0
Isopropyl-carbamic acid 5-(4-fluoro-phenyl)-7-isopropylcarbamoyloxymethyl-2,3-dihydro-pyrrolo[2,1-b]thiazol-6-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / LiAlH₄ / CH₂Cl₂; diethyl ether / 1 h / Heating

2: 95 percent / Et₃N / CH₂Cl₂ / Heating

With lithium aluminium tetrahydride; triethylamine; In diethyl ether; dichloromethane;
DOI:10.1021/jm00402a030