5-(4-Fluoro-phenyl)-2,3-dihydro-pyrrolo[2,1-b]thiazole-6,7-dicarboxylic acid dimethyl ester

Base Information

Chemical Name:5-(4-Fluoro-phenyl)-2,3-dihydro-pyrrolo[2,1-b]thiazole-6,7-dicarboxylic acid dimethyl ester
CAS No.:114199-28-9
Molecular Formula:C₁₆H₁₄FNO₄S
Molecular Weight:335.356
Hs Code.:

Synonyms:5-(4-Fluoro-phenyl)-2,3-dihydro-pyrrolo[2,1-b]thiazole-6,7-dicarboxylic acid dimethyl ester

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Chemical Property of 5-(4-Fluoro-phenyl)-2,3-dihydro-pyrrolo[2,1-b]thiazole-6,7-dicarboxylic acid dimethyl ester

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Technology Process of 5-(4-Fluoro-phenyl)-2,3-dihydro-pyrrolo[2,1-b]thiazole-6,7-dicarboxylic acid dimethyl ester

There total 1 articles about 5-(4-Fluoro-phenyl)-2,3-dihydro-pyrrolo[2,1-b]thiazole-6,7-dicarboxylic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 762-42-5
dimethyl acetylenedicarboxylate

: 114199-23-4
3-(4-Fluorobenzoyl)thiazolidinecarboxylic acid

: 114199-28-9
5-(4-Fluoro-phenyl)-2,3-dihydro-pyrrolo[2,1-b]thiazole-6,7-dicarboxylic acid dimethyl ester

Guidance literature:: With acetic anhydride; Heating;
DOI:10.1021/jm00402a030

Reference yield: 97.0%

: 114199-28-9
5-(4-Fluoro-phenyl)-2,3-dihydro-pyrrolo[2,1-b]thiazole-6,7-dicarboxylic acid dimethyl ester

: 114199-33-6
5-(4-fluorophenyl)-2,3-dihydropyrrolo<2,1-b>thiazole-6,7-dimethanol

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; dichloromethane; for 1h; Heating;
DOI:10.1021/jm00402a030

Reference yield:

: 114199-28-9
5-(4-Fluoro-phenyl)-2,3-dihydro-pyrrolo[2,1-b]thiazole-6,7-dicarboxylic acid dimethyl ester

: 114199-37-0
Isopropyl-carbamic acid 5-(4-fluoro-phenyl)-7-isopropylcarbamoyloxymethyl-2,3-dihydro-pyrrolo[2,1-b]thiazol-6-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / LiAlH₄ / CH₂Cl₂; diethyl ether / 1 h / Heating

2: 95 percent / Et₃N / CH₂Cl₂ / Heating

With lithium aluminium tetrahydride; triethylamine; In diethyl ether; dichloromethane;
DOI:10.1021/jm00402a030