C₂₄H₂₂F₃N₅O₃

Base Information

Chemical Name:C₂₄H₂₂F₃N₅O₃
CAS No.:1620413-35-5
Molecular Formula:C₂₄H₂₂F₃N₅O₃
Molecular Weight:485.466
Hs Code.:

C<sub>24</sub>H<sub>22</sub>F<sub>3</sub>N<sub>5</sub>O<sub>3</sub>

Synonyms:C₂₄H₂₂F₃N₅O₃

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Chemical Property of C₂₄H₂₂F₃N₅O₃

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Technology Process of C₂₄H₂₂F₃N₅O₃

There total 16 articles about C₂₄H₂₂F₃N₅O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 69949-67-3
(RS)-3-Bromo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-2-one

: C₁₃H₁₄N₄O₂

: 1620413-35-5
C₂₄H₂₂F₃N₅O₃

: 1620411-27-9
C₂₄H₂₂F₃N₅O₃

Guidance literature:: C₁₃H₁₄N₄O₂; With 15-crown-5; sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 1h; Inert atmosphere;

(RS)-3-Bromo-1-(3-trifluoromethyl-phenyl)-pyrrolidin-2-one; In N,N-dimethyl-formamide; at 20 ℃; for 1.5h; Overall yield = 28 mg; Optical yield = 77.778 %de; Inert atmosphere;

Reference yield:

: C₂₄H₂₆N₂O₄

: 1620413-35-5
C₂₄H₂₂F₃N₅O₃

: 1620411-27-9
C₂₄H₂₂F₃N₅O₃

Guidance literature:: Multi-step reaction with 10 steps

1.1: hydrogen; palladium 10% on activated carbon / methanol / 6 h / 0 - 20 °C

2.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C / Inert atmosphere

3.1: bromine / dichloromethane; acetic acid / 20 °C / Inert atmosphere

4.1: potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tetrahydrofuran / 0.17 h / 20 °C / Inert atmosphere

4.2: 3.17 h / 20 - 90 °C / Inert atmosphere

5.1: hydrogenchloride / methanol; isopropyl alcohol / 20 °C

6.1: acetic anhydride / 0.5 h / 20 °C

6.2: 16 h / 60 °C

7.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 16 h / 20 °C

8.1: ammonium acetate / acetic acid / 1 h / Reflux

9.1: trifluorormethanesulfonic acid / toluene / 2 h / Reflux

10.1: 15-crown-5; sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

10.2: 1.5 h / 20 °C / Inert atmosphere

With hydrogenchloride; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 15-crown-5; trifluorormethanesulfonic acid; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; ammonium acetate; hydrogen; bromine; acetic anhydride; sodium hydride; potassium carbonate; triphenylphosphine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; potassium iodide; In tetrahydrofuran; methanol; dichloromethane; acetic acid; N,N-dimethyl-formamide; isopropyl alcohol; toluene;

Reference yield:

: C₁₇H₂₀N₂O₄

: 1620413-35-5
C₂₄H₂₂F₃N₅O₃

: 1620411-27-9
C₂₄H₂₂F₃N₅O₃

Guidance literature:: Multi-step reaction with 5 steps

1.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 20 °C / Inert atmosphere

2.1: trifluorormethanesulfonic acid; trifluoroacetic acid; methoxybenzene / 2 h / 50 °C

3.1: bromine / dichloromethane; acetic acid / 4 h / 20 °C

4.1: potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2-di-tertbutylphosphino-3,4,5,6-tetramethyl-2',4',6'-triisopropyl-1,1'-biphenyl / toluene; 1,4-dioxane / 5 h / 120 °C / Inert atmosphere

5.1: 15-crown-5; sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

5.2: 1.5 h / 20 °C / Inert atmosphere

With 2-di-tertbutylphosphino-3,4,5,6-tetramethyl-2',4',6'-triisopropyl-1,1'-biphenyl; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 15-crown-5; trifluorormethanesulfonic acid; di-isopropyl azodicarboxylate; bromine; sodium hydride; methoxybenzene; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; acetic acid; N,N-dimethyl-formamide; toluene;