1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(6-(5-fluoro-2-oxo-1,2-dihydropyridin-4-yl)-5-methylpyridin-2-yl)cyclopropanecarboxamide

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Chemical Name:1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(6-(5-fluoro-2-oxo-1,2-dihydropyridin-4-yl)-5-methylpyridin-2-yl)cyclopropanecarboxamide
CAS No.:1083168-23-3
Molecular Formula:C₂₂H₁₆F₃N₃O₄
Molecular Weight:443.382
Hs Code.:

Synonyms:1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(6-(5-fluoro-2-oxo-1,2-dihydropyridin-4-yl)-5-methylpyridin-2-yl)cyclopropanecarboxamide

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Chemical Property of 1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(6-(5-fluoro-2-oxo-1,2-dihydropyridin-4-yl)-5-methylpyridin-2-yl)cyclopropanecarboxamide

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Technology Process of 1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(6-(5-fluoro-2-oxo-1,2-dihydropyridin-4-yl)-5-methylpyridin-2-yl)cyclopropanecarboxamide

There total 15 articles about 1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(6-(5-fluoro-2-oxo-1,2-dihydropyridin-4-yl)-5-methylpyridin-2-yl)cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1083168-22-2
1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(5'-fluoro-2'-methoxy-3-methyl-2,4'-bipyridin-6-yl)cyclopropanecarboxamide

: 1083168-23-3
1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(6-(5-fluoro-2-oxo-1,2-dihydropyridin-4-yl)-5-methylpyridin-2-yl)cyclopropanecarboxamide

Guidance literature:: With trimethylsilyl iodide; In chloroform; at 20 ℃; for 2h;

Reference yield:

: 442129-37-5
6-amino-2-chloro-3-methylpyridine

: 1083168-23-3
1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(6-(5-fluoro-2-oxo-1,2-dihydropyridin-4-yl)-5-methylpyridin-2-yl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 18 h / 20 °C

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.33 h / 120 °C / microwave irradiation

3: trimethylsilyl iodide / chloroform / 2 h / 20 °C

With trimethylsilyl iodide; sodium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; dichloromethane; chloroform; water;

Reference yield:

: 1603-41-4
(5-methyl-pyridin-2-yl)amine

: 1083168-23-3
1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(6-(5-fluoro-2-oxo-1,2-dihydropyridin-4-yl)-5-methylpyridin-2-yl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

2.1: dihydrogen peroxide; acetic acid / water / 12 h / 20 - 80 °C

3.1: triethylamine / dichloromethane / 0.5 h / 20 °C

3.2: 15 h / 50 °C

4.1: hydrogenchloride; water / 12 h / 80 °C

4.2: pH 8 - 9

5.1: triethylamine / dichloromethane / 18 h / 20 °C

6.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.33 h / 120 °C / microwave irradiation

7.1: trimethylsilyl iodide / chloroform / 2 h / 20 °C

With hydrogenchloride; trimethylsilyl iodide; water; dihydrogen peroxide; sodium carbonate; acetic acid; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; dichloromethane; chloroform; water;