442129-37-5

Usage

Uses

Used in Pharmaceutical Industry:
2-Pyridinamine, 6-chloro-5-methyl is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure allows it to bind to biological receptors and enzymes, making it a valuable component in the development of drugs for different medical conditions.
Used in Agrochemical Industry:
In the agrochemical industry, 2-Pyridinamine, 6-chloro-5-methyl is utilized as an intermediate in the production of agrochemicals. Its properties enable it to be incorporated into compounds that can be used in the development of pesticides, herbicides, and other agricultural chemicals to improve crop yields and protect plants from pests.
Used in Organic Synthesis:
2-Pyridinamine, 6-chloro-5-methyl is used as a building block in organic synthesis for the creation of more complex molecules. Its versatile structure allows it to be a key component in the synthesis of a wide range of organic compounds, contributing to the advancement of chemical research and the development of new materials and products.

Upstream product

• 1603-41-4 (5-methyl-pyridin-2-yl)amine 
• 358672-65-8 5-bromo-6-chloropyridin-2-ylamine 
• 94242-85-0 2,4,4,5,5-pentamethyl-[1,3,2]dioxaborolane 
• 45644-21-1 6-chloropyridin-2-amine 
• 80364-46-1 N-(6-chloropyridin-2-yl)acetamide 
• 13061-96-6 dihydroxy-methyl-borane 
• 18368-76-8 2 chloro-3-methylpyridine 
• 91668-83-6 2-Chloro-3-methylpyridine N-oxide 
• 141-43-5 ethanolamine 
• 171520-82-4 5-methyl-2-pivaloylaminopyridine N-oxide 
• 86847-78-1 2,2-Dimethyl-N-(5-methyl-2-pyridinyl)propanamide 
• 19230-57-0 2-bromo-3-methylpyridine 1-oxide 
• 936727-56-9 N-(6-chloro-5-methyl-pyridin-2-yl)-2,2-dimethyl-propionamide 

Downstream Products

• 936727-60-5 1-(benzo[d][1,3]dioxol-5-yl)-N-(6-chloro-5-methylpyridin-2-yl)cyclopropanecarboxamide 
• 1083168-97-1 N-(6-chloro-5-methylpyridin-2-yl)-1-(2,3-dihydro-1H-inden-5-yl)cyclopropanecarboxamide 
• 936727-68-3 N-(6-chloro-5-methylpyridin-2-yl)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropane-1-carboxamide 
• 1083168-82-4 6'-methoxy-3,5'-dimethyl-2,3'-bipyridin-6-amine 
• 936727-05-8 Lumacaftor 
• 1083168-51-7 1-(4-chlorophenyl)-N-(5-methyl-6-(5-methyl-6-oxo-1,6-dihydropyridin-3-yl)pyridin-2-yl)cyclopropanecarboxamide 
• 1083168-58-4 1-(3-methoxyphenyl)-N-(5-methyl-6-(5-methyl-6-oxo-1,6-dihydropyridin-3-yl)pyridin-2-yl)cyclopropanecarboxamide 
• 1083168-98-2 N-(6'-methoxy-3,5'-dimethyl-2,3'-bipyridin-6-yl)-1-(3-methoxyphenyl)cyclopropanecarboxamide 
• 1083168-50-6 C₂₃H₂₂ClN₃O₂ 
• 1083167-66-1 1-(benzo[d][1,3]dioxol-5-yl)-N-(6'-methoxy-3-methyl-2,3'-bipyridin-6-yl)cyclopropanecarboxamide 
• 1083168-53-9 1-(3-chloro-4-methoxyphenyl)-N-(5-methyl-6-(5-methyl-6-oxo-1,6-dihydropyridin-3-yl)pyridin-2-yl)cyclopropanecarboxamide 
• 1083167-75-2 1-(2,3-dihydro-1H-inden-5-yl)-N-(5-methyl-6-(6-oxo-1,6-dihydropyridin-3-yl)pyridin-2-yl)cyclopropanecarboxamide 
• 1083168-52-8 1-(3-chloro-4-methoxyphenyl)-N-(6'-methoxy-3,5'-dimethyl-2,3'-bipyridin-6-yl)cyclopropanecarboxamide 
• 1083167-74-1 1-(2,3-dihydro-1H-inden-5-yl)-N-(6'-methoxy-3-methyl-2,3'-bipyridin-6-yl)cyclopropanecarboxamide 

Relevant academic research and scientific papers

Improved Synthesis of 6-Chloro-5-methylpyridin-2-amine: A Key Intermediate for Making Lumacaftor

A safe and efficient synthesis of 6-chloro-5-methylpyridin-2-amine, a key intermediate for lumacaftor, is described, which avoids the utilization of peroxide. In this four-step sequence, starting from 2-amino-6-chloropyridine, the crucial 5-position methylation was achieved via a Suzuki-Miyaura cross-coupling reaction. By adopting this synthetic route, 6-chloro-5-methylpyridin-2-amine was produced on a hectogram scale with 62.4% overall yield and 99.49% purity.

Technological method for preparing 2- amino -6-5-methyl-substituted-pyridine (by machine translation)

The reaction solvent of 2 - the method is reacted in a reaction solvent under the action, of 2 - an, acid anhydride and an acid,binding, agent and an amination reagent under the action. of an acid anhydride and 2 - an acid-binding agent and, an amination reagent, 2 -4 - 93/7, 99.8%, 70%. (by machine translation)

2 - Chloro -3 - methyl -6 - acyl aminopyridine and its preparation and use (by machine translation)

The invention belongs to the field of pharmaceutical chemistry and chemical synthesis, in particular to the invention belongs to the field of pharmaceutical chemistry and chemical synthesis, in particular relates to a 2 - chloro - 3 - methyl - 6 - acyl aminopyridine and its preparation and use. The invention provides the following the general formula II of said 2 - chloro - 3 - methyl - 6 - acyl amino pyridine or its pharmaceutically acceptable salt, ester, prodrug or solvate thereof, and [...] fibrosis is an important intermediate of the active ingredient. Through formula II compound represented by the general formula IA or IB obtained compound can be directly used for preparing [...] fibrosis drug. The invention provides general formula IA or IB that the synthesis of the compounds has the following advantages: the security, the method is simple, high yield, it is suitable for industrial production. (by machine translation)

PROCESS FOR PREPARATION OF LUMACAFTOR

The present invention relates to a process for the preparation of amorphous lumacaftor. The present invention relates to a process for the preparation of intermediate 6-amino-2- halo-3-methylpyridine compounds used in the preparation of lumacaftor. The present invention relates to lumacaftor hydrobromide, process for its preparation and conversion thereof to lumacaftor.

Synthesis of 5-bromo-6-methyl imidazopyrazine, 5-bromo and 5-chloro-6-methyl imidazopyridine using electron density surface maps to guide synthetic strategy

Small heteroaromatic rings are valuable monomers in drug discovery that can enable rapid access to novel and desirable chemical space. Installation of a synthetic handle on a heteroaromatic core may be difficult if steric and electronic factors are not in alignment with the desired transformation. Described are practical routes for the construction of 5-bromo-6-methyl imidazopyrazine (1) as well as 5-bromo and 5-chloro-6-methyl imidazopyridines (2a and 2b), which were developed using electron density surface maps encoded with ionization potential to guide synthetic strategy.

MODULATORS OF CFTR

Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating CFTR mediated diseases using compounds of the present invention.