Technology Process of benzyl 5-methoxy-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate
There total 6 articles about benzyl 5-methoxy-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
5-methoxy-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid;
With
diphenyl phosphoryl azide; triethylamine;
In
benzene;
at 80 ℃;
for 6h;
benzyl alcohol;
In
benzene;
at 80 ℃;
for 30h;
DOI:10.1080/00397911.2010.495043
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: copper(l) iodide / methanol; N,N-dimethyl-formamide / 72 h / Reflux
2.1: sodium hydroxide / methanol; water / 12 h / 20 °C
2.2: pH 2
3.1: ammonia; sodium / tetrahydrofuran / 2.5 h / -70 °C / Inert atmosphere
3.2: ice / pH 3
4.1: diphenyl phosphoryl azide; triethylamine / benzene / 6 h / 80 °C
4.2: 30 h / 80 °C
With
copper(l) iodide; diphenyl phosphoryl azide; ammonia; sodium; triethylamine; sodium hydroxide;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; benzene;
3.1: Birch reduction / 4.1: Curtius rearrangement;
DOI:10.1080/00397911.2010.495043
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: toluene-4-sulfonic acid / 24 h / 64 °C
2.1: copper(l) iodide / methanol; N,N-dimethyl-formamide / 72 h / Reflux
3.1: sodium hydroxide / methanol; water / 12 h / 20 °C
3.2: pH 2
4.1: ammonia; sodium / tetrahydrofuran / 2.5 h / -70 °C / Inert atmosphere
4.2: ice / pH 3
5.1: diphenyl phosphoryl azide; triethylamine / benzene / 6 h / 80 °C
5.2: 30 h / 80 °C
With
copper(l) iodide; diphenyl phosphoryl azide; ammonia; sodium; toluene-4-sulfonic acid; triethylamine; sodium hydroxide;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; benzene;
4.1: Birch reduction / 5.1: Curtius rearrangement;
DOI:10.1080/00397911.2010.495043
