2-ethoxy-5-nitrobenzoic acid

Base Information

• Chemical Name: 2-ethoxy-5-nitrobenzoic acid
• CAS No.: 57148-23-9
• Molecular Formula: C₉H₉NO₅
• Molecular Weight: 211.174
• Mol file: 57148-23-9.mol

Synonyms:2-ethoxy-5-nitro-benzoic acid

Chemical Property of 2-ethoxy-5-nitrobenzoic acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

2-Ethoxy-5-nitrobenzoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-ethoxy-5-nitrobenzoic acid

There total 22 articles about 2-ethoxy-5-nitrobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.7%

2-ethoxy-5-nitro-benzoic acid methyl ester (80074-34-6) → 2-ethoxy-5-nitro-benzoic acid (57148-23-9)

Guidance literature:

With potassium hydroxide; at 60 - 80 ℃;

Reference yield: 97.7%

5-amino-2-ethoxybenzoic acid methyl ester → 2-ethoxy-5-nitro-benzoic acid (57148-23-9)

Guidance literature:

With potassium hydroxide; In methanol; at 80 ℃; for 3h;

DOI:10.1016/j.ejmech.2017.12.064

Reference yield: 87.0%

2-ethoxy-5-nitro-benzoic acid ethyl ester (80074-90-4) → 2-ethoxy-5-nitro-benzoic acid (57148-23-9)

Guidance literature:

With water; sodium hydroxide; at 40 ℃; for 15h;

DOI:10.1002/anie.201503607

upstream raw materials:

2-chloro-5-nitrobenzoic acid

2-ethoxylbenzaldehyde

2-ethoxybenzoic acid

2-ethoxy-5-nitrobenzaldehyde

Downstream raw materials:

2-ethoxy-5-amino-benzoic acid

5-acetylamino-2-ethoxy-benzoic acid

2-ethoxy-5-nitro-N-(4-trifluoromethylphenyl)benzamide

5-amino-2-ethoxy-N-(4-trifluoromethylphenyl)benzamide

Refernces

• 1、 Du, Yongli,Zhang, Yanhui,Ling, Hao,Li, Qunyi,Shen, Jingkang. "Discovery of novel high potent and cellular active ADC type PTP1B inhibitors with selectivity over TC-PTP via modification interacting with C site". . p. 692 - 700. Retrieved 2018/01/01.
• 2、 -. "CTB-PI POLYAMIDE CONJUGATE FOR ACTIVATING EXPRESSION OF SPECIFIC GENE". . . Retrieved 2018/01/13.