isopropyl 3-(2-(((((3aR,4R,6R,6aR)-6-(2,6-diamino-9H-purin-9-yI)-6a-methyl-2-oxotetrahydrofuro[3,4-d][1,3]dioxoI-4-yI)methoxy)(((S)-1-isopropoxy-1-oxopropan-2-yI)amino)phosphoryl)oxy)phenyl)propanoate

Base Information

• Chemical Name: isopropyl 3-(2-(((((3aR,4R,6R,6aR)-6-(2,6-diamino-9H-purin-9-yI)-6a-methyl-2-oxotetrahydrofuro[3,4-d][1,3]dioxoI-4-yI)methoxy)(((S)-1-isopropoxy-1-oxopropan-2-yI)amino)phosphoryl)oxy)phenyl)propanoate
• CAS No.: 1412427-38-3
• Molecular Formula: C₃₀H₄₀N₇O₁₁P
• Molecular Weight: 705.662
• Mol file: 1412427-38-3.mol

Synonyms:isopropyl 3-(2-(((((3aR,4R,6R,6aR)-6-(2,6-diamino-9H-purin-9-yI)-6a-methyl-2-oxotetrahydrofuro[3,4-d][1,3]dioxoI-4-yI)methoxy)(((S)-1-isopropoxy-1-oxopropan-2-yI)amino)phosphoryl)oxy)phenyl)propanoate

Chemical Property of isopropyl 3-(2-(((((3aR,4R,6R,6aR)-6-(2,6-diamino-9H-purin-9-yI)-6a-methyl-2-oxotetrahydrofuro[3,4-d][1,3]dioxoI-4-yI)methoxy)(((S)-1-isopropoxy-1-oxopropan-2-yI)amino)phosphoryl)oxy)phenyl)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of isopropyl 3-(2-(((((3aR,4R,6R,6aR)-6-(2,6-diamino-9H-purin-9-yI)-6a-methyl-2-oxotetrahydrofuro[3,4-d][1,3]dioxoI-4-yI)methoxy)(((S)-1-isopropoxy-1-oxopropan-2-yI)amino)phosphoryl)oxy)phenyl)propanoate

There total 4 articles about isopropyl 3-(2-(((((3aR,4R,6R,6aR)-6-(2,6-diamino-9H-purin-9-yI)-6a-methyl-2-oxotetrahydrofuro[3,4-d][1,3]dioxoI-4-yI)methoxy)(((S)-1-isopropoxy-1-oxopropan-2-yI)amino)phosphoryl)oxy)phenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

isopropyl 3-(2-(((((3aR,4R,6R,6aR)-6-(2-amino-6-chIoro-9H-purin-9-yI)-6a-methyl-2-oxotetrahydrofuro[3,4-d][1,3]dioxoI-4-yI)methoxy)(((S)-1-isopropoxy-1-oxopropan-2-yI)amino)phosphoryl)oxy)phenyl)propanoate (1412427-37-2) → isopropyl 3-(2-(((((3aR,4R,6R,6aR)-6-(2,6-diamino-9H-purin-9-yI)-6a-methyl-2-oxotetrahydrofuro[3,4-d][1,3]dioxoI-4-yI)methoxy)(((S)-1-isopropoxy-1-oxopropan-2-yI)amino)phosphoryl)oxy)phenyl)propanoate (1412427-38-3) + isopropyl 3-(2-(((((3aR,4R,6R,6aR)-6-(2,6-diamino-9H-purin-9-yI)-6a-methyl-2-oxotetrahydrofuro[3,4-d][1,3]dioxoI-4-yI)methoxy)(((S)-1-isopropoxy-1-oxopropan-2-yI)amino)phosphoryl)oxy)phenyl)propanoate (1412427-39-4)

Guidance literature:

isopropyl 3-(2-(((((3aR,4R,6R,6aR)-6-(2-amino-6-chIoro-9H-purin-9-yI)-6a-methyl-2-oxotetrahydrofuro[3,4-d][1,3]dioxoI-4-yI)methoxy)(((S)-1-isopropoxy-1-oxopropan-2-yI)amino)phosphoryl)oxy)phenyl)propanoate; With sodium azide; In N,N-dimethyl-formamide; at 20 - 70 ℃; for 12h; Inert atmosphere;

With hydrogen; palladium 10% on activated carbon; In ethyl acetate; isopropyl alcohol; for 18h; under 2585.81 Torr;

Reference yield:

(2R,3R,4R,5R)-2-(2-amino-6-chloro-9H-purin-9-yl)-5-(hydroxymethyl)-3-methyltetrahydrofuran-3,4-diol (640725-74-2) → isopropyl 3-(2-(((((3aR,4R,6R,6aR)-6-(2,6-diamino-9H-purin-9-yI)-6a-methyl-2-oxotetrahydrofuro[3,4-d][1,3]dioxoI-4-yI)methoxy)(((S)-1-isopropoxy-1-oxopropan-2-yI)amino)phosphoryl)oxy)phenyl)propanoate (1412427-38-3) + isopropyl 3-(2-(((((3aR,4R,6R,6aR)-6-(2,6-diamino-9H-purin-9-yI)-6a-methyl-2-oxotetrahydrofuro[3,4-d][1,3]dioxoI-4-yI)methoxy)(((S)-1-isopropoxy-1-oxopropan-2-yI)amino)phosphoryl)oxy)phenyl)propanoate (1412427-39-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 1H-imidazole; pyridine / 6 h / 0 °C / Inert atmosphere

2.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 4 h / 0 °C / Inert atmosphere

2.2: 12 h / 0 - 20 °C / Inert atmosphere

3.1: 1-methyl-1H-imidazole / tetrahydrofuran / 12 h / -78 - 20 °C / Inert atmosphere

4.1: sodium azide / N,N-dimethyl-formamide / 12 h / 20 - 70 °C / Inert atmosphere

4.2: 18 h / 2585.81 Torr

With pyridine; 1H-imidazole; 1-methyl-1H-imidazole; sodium azide; 1,1'-carbonyldiimidazole; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

(2R,3R,4R,5R)-2-(2-amino-6-chIoro-9H-purin-9-yI)-5-(((tertbutyldimethylsilyl)oxy)methyl)-3-methyltetrahydrofuran-3,4-diol (1412427-35-0) → isopropyl 3-(2-(((((3aR,4R,6R,6aR)-6-(2,6-diamino-9H-purin-9-yI)-6a-methyl-2-oxotetrahydrofuro[3,4-d][1,3]dioxoI-4-yI)methoxy)(((S)-1-isopropoxy-1-oxopropan-2-yI)amino)phosphoryl)oxy)phenyl)propanoate (1412427-38-3) + isopropyl 3-(2-(((((3aR,4R,6R,6aR)-6-(2,6-diamino-9H-purin-9-yI)-6a-methyl-2-oxotetrahydrofuro[3,4-d][1,3]dioxoI-4-yI)methoxy)(((S)-1-isopropoxy-1-oxopropan-2-yI)amino)phosphoryl)oxy)phenyl)propanoate (1412427-39-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 4 h / 0 °C / Inert atmosphere

1.2: 12 h / 0 - 20 °C / Inert atmosphere

2.1: 1-methyl-1H-imidazole / tetrahydrofuran / 12 h / -78 - 20 °C / Inert atmosphere

3.1: sodium azide / N,N-dimethyl-formamide / 12 h / 20 - 70 °C / Inert atmosphere

3.2: 18 h / 2585.81 Torr

With 1-methyl-1H-imidazole; sodium azide; 1,1'-carbonyldiimidazole; In tetrahydrofuran; N,N-dimethyl-formamide;

upstream raw materials:

(2R,3R,4R,5R)-2-(2-amino-6-chloro-9H-purin-9-yl)-5-(hydroxymethyl)-3-methyltetrahydrofuran-3,4-diol

C₁₈H₂₇ClNO₆P

(3aR,4R,6R,6aR)-4-(2-amino-6-chIoro-9H-purin-9-yI)-6-(hydroxymethyl)-3a-methyltetrahydroturo[3,4-d] [1,3]dioxol-2-one

(2R,3R,4R,5R)-2-(2-amino-6-chIoro-9H-purin-9-yI)-5-(((tertbutyldimethylsilyl)oxy)methyl)-3-methyltetrahydrofuran-3,4-diol