6,11-DIOXO-6,11-DIHYDRO-BENZO[F]PYRIDO[1,2-A]INDOLE-12-CARBOXYLIC ACID

Base Information

• Chemical Name: 6,11-DIOXO-6,11-DIHYDRO-BENZO[F]PYRIDO[1,2-A]INDOLE-12-CARBOXYLIC ACID
• CAS No.: 109964-49-0
• Molecular Formula: C₁₇H₉NO₄
• Molecular Weight: 291.263
• Mol file: 109964-49-0.mol

Synonyms:6,11-dioxo-6,11-dihydrobenzo[f]pyrido[1,2-a]indole-12-carboxylic acid

Chemical Property of 6,11-DIOXO-6,11-DIHYDRO-BENZO[F]PYRIDO[1,2-A]INDOLE-12-CARBOXYLIC ACID

Chemical Property:

• Melting Point: 313-314 °C
• PKA: 0.98±0.20(Predicted)
• Density: 1.51±0.1 g/cm3(Predicted)

Purity/Quality:

6,11-dioxo-6,11-dihydrobenzo[f]pyrido[1,2-a]indole-12-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6,11-DIOXO-6,11-DIHYDRO-BENZO[F]PYRIDO[1,2-A]INDOLE-12-CARBOXYLIC ACID

There total 10 articles about 6,11-DIOXO-6,11-DIHYDRO-BENZO[F]PYRIDO[1,2-A]INDOLE-12-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

pyridine (110-86-1) + 2,3-Dichloro-1,4-naphthoquinone (117-80-6) + cycl-isopropylidene malonate (2033-24-1) → 6,11-dioxo-6,11-dihydrobenzo[f]pyrido[1,2-a]indole-12-carboxylic acid (109964-49-0)

Guidance literature:

In ethanol; for 6h; Reflux;

DOI:10.4067/S0717-97072012000200015

Reference yield: 93.0%

methyl 6,11-dioxo-6,11- dihydrobenzo[f]pyrido [1,2-a]indole-12-carboxylate (98596-13-5) → 6,11-dioxo-6,11-dihydrobenzo[f]pyrido[1,2-a]indole-12-carboxylic acid (109964-49-0)

Guidance literature:

With water; potassium carbonate; In methanol;

DOI:10.1016/j.bmc.2018.08.028

Reference yield:

2,3-Dichloro-1,4-naphthoquinone (117-80-6) → 6,11-dioxo-6,11-dihydrobenzo[f]pyrido[1,2-a]indole-12-carboxylic acid (109964-49-0)

Guidance literature:

Multi-step reaction with 3 steps

1: ethanol

2: iodine; pyridine

3: aqueous NaOH

With pyridine; sodium hydroxide; ethanol; iodine;

DOI:10.1021/ja01562a048

upstream raw materials:

methyl 6,11-dioxo-6,11- dihydrobenzo[f]pyrido [1,2-a]indole-12-carboxylate

6,11-dioxo-6,11-dihydro-benzo[f]pyrido[1,2-a]indole-12-carboxylic acid ethyl ester

1-[2-(6,11-dioxo-6,11-dihydro-benzo[f]pyrido[1,2-a]indol-12-yl)-2-oxo-ethyl]-pyridinium; iodide

pyridine

Downstream raw materials:

6,11-dioxo-6,11-dihydro-benzo[f]pyrido[1,2-a]indole-12-carboxylic acid p-phenetidide

6,11-dioxo-6,11-dihydro-benzo[f]pyrido[1,2-a]indole-12-carboxylic acid-(4-acetylamino-anilide)

1-Carbamoyl-2,3-phthaloyl-pyrrocolin

6,11-dioxo-6,11-dihydro-benzo[f]pyrido[1,2-a]indole-12-carboxylic acid anilide