1-BENZYL-5-NITRO-1H-INDAZOLE

Base Information

• Chemical Name: 1-BENZYL-5-NITRO-1H-INDAZOLE
• CAS No.: 23856-20-4
• Molecular Formula: C14H11 N3 O2
• Molecular Weight: 253.26
• Hs Code.: 2933990090
• Mol file: 23856-20-4.mol

Synonyms:1H-Indazole,1-benzyl-5-nitro- (8CI); 1-Benzyl-5-nitro-1H-indazole; 1-Benzyl-5-nitroindazole

Chemical Property of 1-BENZYL-5-NITRO-1H-INDAZOLE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 451.084°C at 760 mmHg
• Flash Point: 226.608°C
• PSA: 63.64000
• Density: 1.31g/cm³
• LogP: 3.51600
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

1-Benzyl-5-nitro-1H-indazole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BENZYL-5-NITRO-1H-INDAZOLE

There total 10 articles about 1-BENZYL-5-NITRO-1H-INDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-benzyl-5-nitro-1H-indazol-3-amine (451459-99-7) → 5-nitro-1-(phenylmethyl)-1H-indazole (23856-20-4)

Guidance literature:

With tert.-butylnitrite; In tetrahydrofuran; for 1h; Reflux;

DOI:10.1016/j.tet.2013.03.042

Reference yield: 52.0%

benzyl chloride (100-44-7) + 5-nitroindazole (5401-94-5) → C14H13N3O2 + 5-nitro-1-(phenylmethyl)-1H-indazole (23856-20-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 24h;

DOI:10.1016/j.ejmech.2018.06.011

Reference yield: 44.0%

benzyl bromide (100-39-0) + 5-nitroindazole (5401-94-5) → 5-nitro-1-(phenylmethyl)-1H-indazole (23856-20-4)

Guidance literature:

With potassium carbonate; In acetonitrile; at 70 ℃;

upstream raw materials:

benzyl bromide

5-nitroindazole

2-fluoro-5-nitrobenzaldehye

Benzylhydrazine

Downstream raw materials:

1-benzyl-1H-indazol-5-ylamine

C₂₉H₂₅N₇O

C₃₀H₂₇N₇

C₂₉H₂₇N₇

Refernces

• 1、 Milik, Sandra N.,Abdel-Aziz, Amal Kamal,Lasheen, Deena S.,Serya, Rabah A.T.,Minucci, Saverio,Abouzid, Khaled A.M.. "Surmounting the resistance against EGFR inhibitors through the development of thieno[2,3-d]pyrimidine-based dual EGFR/HER2 inhibitors". supporting information. p. 316 - 336. Retrieved 2018/06/14.
• 2、 -. "Bicyclic heteroaromatic compounds as protein tyrosine kinase inhibitors". Page/Page column 39. . Retrieved 2015/12/18.