N₁-({4-[(2,4-dichlorophenyl)sulfonyl]-2-morpholinyl}methyl)-N₂-{[(1,1-dimethylethyl)oxy]carbonyl}-L-leucinamide

Base Information

• Chemical Name: N₁-({4-[(2,4-dichlorophenyl)sulfonyl]-2-morpholinyl}methyl)-N₂-{[(1,1-dimethylethyl)oxy]carbonyl}-L-leucinamide
• CAS No.: 911641-09-3
• Molecular Formula: C₂₂H₃₃Cl₂N₃O₆S
• Molecular Weight: 538.493

Synonyms:N₁-({4-[(2,4-dichlorophenyl)sulfonyl]-2-morpholinyl}methyl)-N₂-{[(1,1-dimethylethyl)oxy]carbonyl}-L-leucinamide

Chemical Property of N₁-({4-[(2,4-dichlorophenyl)sulfonyl]-2-morpholinyl}methyl)-N₂-{[(1,1-dimethylethyl)oxy]carbonyl}-L-leucinamide

Chemical Property:

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Technology Process of N₁-({4-[(2,4-dichlorophenyl)sulfonyl]-2-morpholinyl}methyl)-N₂-{[(1,1-dimethylethyl)oxy]carbonyl}-L-leucinamide

There total 4 articles about N₁-({4-[(2,4-dichlorophenyl)sulfonyl]-2-morpholinyl}methyl)-N₂-{[(1,1-dimethylethyl)oxy]carbonyl}-L-leucinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N2-{[(1,1-dimethylethyl)oxy]carbonyl}-N1-(2-morpholinylmethyl)-L-leucinamide (911641-08-2) + 2,4-Dichlorobenzenesulfonyl chloride (16271-33-3) → N1-({4-[(2,4-dichlorophenyl)sulfonyl]-2-morpholinyl}methyl)-N2-{[(1,1-dimethylethyl)oxy]carbonyl}-L-leucinamide (911641-09-3)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 120h;

Reference yield:

N2-{[(1,1-dimethylethyl)oxy]carbonyl}-N1-{[4-(phenylmethyl)-2-morpholinyl]methyl}-L-leucinamide (911641-07-1) → N1-({4-[(2,4-dichlorophenyl)sulfonyl]-2-morpholinyl}methyl)-N2-{[(1,1-dimethylethyl)oxy]carbonyl}-L-leucinamide (911641-09-3)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 27 h

2: triethylamine / dichloromethane / 120 h / 20 °C

With hydrogen; triethylamine; palladium 10% on activated carbon; In methanol; dichloromethane;

Reference yield:

N-tert-butoxycarbonyl-L-leucine (13139-15-6,53296-34-7) → N1-({4-[(2,4-dichlorophenyl)sulfonyl]-2-morpholinyl}methyl)-N2-{[(1,1-dimethylethyl)oxy]carbonyl}-L-leucinamide (911641-09-3)

Guidance literature:

Multi-step reaction with 3 steps

1: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine / dichloromethane / 23 h / 20 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 27 h

3: triethylamine / dichloromethane / 120 h / 20 °C

With hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium 10% on activated carbon; In methanol; dichloromethane;

upstream raw materials:

N₂-{[(1,1-dimethylethyl)oxy]carbonyl}-N₁-(2-morpholinylmethyl)-L-leucinamide

2,4-Dichlorobenzenesulfonyl chloride

N₂-{[(1,1-dimethylethyl)oxy]carbonyl}-N₁-{[4-(phenylmethyl)-2-morpholinyl]methyl}-L-leucinamide

N-tert-butoxycarbonyl-L-leucine

Downstream raw materials:

N₁-({4-[(2,4-dichlorophenyl)sulfonyl]-2-morpholinyl}methyl)-L-leucinamide

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