2-((3-butoxyphenoxy)methyl)quinoline

Base Information

• Chemical Name: 2-((3-butoxyphenoxy)methyl)quinoline
• CAS No.: 107813-90-1
• Molecular Formula: C₂₀H₂₁NO₂
• Molecular Weight: 307.392
• Mol file: 107813-90-1.mol

Synonyms:2-((3-butoxyphenoxy)methyl)quinoline

Chemical Property of 2-((3-butoxyphenoxy)methyl)quinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-((3-butoxyphenoxy)methyl)quinoline

There total 7 articles about 2-((3-butoxyphenoxy)methyl)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-n-butoxyphenol (18979-72-1) + C11H11NO3S → 2-((3-butoxyphenoxy)methyl)quinoline (107813-90-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 12h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.1c01078

Reference yield:

2-Chloromethylquinoline (4377-41-7) + 3-(n-pentoxy)phenol (18979-73-2) → 2-((3-butoxyphenoxy)methyl)quinoline (107813-90-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; acetone; for 48h; Heating;

DOI:10.1021/jm00166a016

Reference yield:

quinoline-2-carboxylic acid methyl ester (19575-07-6) → 2-((3-butoxyphenoxy)methyl)quinoline (107813-90-1)

Guidance literature:

Multi-step reaction with 3 steps

1: diisobutylaluminium hydride / tetrahydrofuran / 8 h / 0 °C / Inert atmosphere

2: triethylamine / diethyl ether / 2.5 h / -20 - 20 °C / Inert atmosphere

3: potassium carbonate / N,N-dimethyl-formamide / 12 h / 100 °C / Inert atmosphere

With diisobutylaluminium hydride; potassium carbonate; triethylamine; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; 3: |Williamson Ether Synthesis;

DOI:10.1021/acs.jmedchem.1c01078

upstream raw materials:

2-Chloromethylquinoline

3-(n-pentoxy)phenol

quinoline-2-carboxylic acid methyl ester

quinolin-2-ylmethanol

Refernces

• 1、 Youssefyeh,Magnien,Lee,Chan,Lin,Galemmo Jr.,Johnson Jr.,Tan,Campbell,Huang,Nuss,Carnathan,Sutherland,Van Inwegen. "Development of a novel series of (2-quinolinylmethoxy)phenyl-containing compounds as high-affinity leukotriene receptor antagonists. 1. Initial structure-activity relationships". . p. 1186 - 1194. Retrieved 2007/10/02.