2-Quinolinylmethanol

Base Information

• Chemical Name: 2-Quinolinylmethanol
• CAS No.: 1780-17-2
• Molecular Formula: C10H9NO
• Molecular Weight: 159.188
• Hs Code.: 2933499090
• European Community (EC) Number: 217-225-7
• NSC Number: 6506
• DSSTox Substance ID: DTXSID60170410
• Nikkaji Number: J47.684F
• Wikidata: Q63408719
• Metabolomics Workbench ID: 97840
• Mol file: 1780-17-2.mol

Synonyms:2-hydroxymethylquinoline

Chemical Property of 2-Quinolinylmethanol

Chemical Property:

• Vapor Pressure: 0.000255mmHg at 25°C
• Melting Point: 64 °C
• Refractive Index: 1.667
• Boiling Point: 310.583 °C at 760 mmHg
• PKA: 14.29±0.10(Predicted)
• Flash Point: 141.636 °C
• PSA: 33.12000
• Density: 1.219 g/cm³
• LogP: 1.72710
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 159.068413911
• Heavy Atom Count: 12
• Complexity: 149

Purity/Quality:

99% ^*data from raw suppliers

2-Quinolinylmethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38-41-37/38
• Safety Statements: 26-36/37/39-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C=CC(=N2)CO
• Uses: Intermediate in the preparation of aminopiperidines and related compounds as MCH receptor modulators useful in the treatment of metabolic, feeding and sexual disorders in humans.

Technology Process of 2-Quinolinylmethanol

There total 34 articles about 2-Quinolinylmethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

quinoline-2-carboxylic acid methyl ester (19575-07-6) → quinolin-2-ylmethanol (1780-17-2)

Guidance literature:

With diisobutylaluminium hydride; In tetrahydrofuran; at 0 ℃; for 8h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.1c01078

Reference yield: 98.0%

quinoline 2-carbaldehyde (5470-96-2) → quinolin-2-ylmethanol (1780-17-2)

Guidance literature:

With methanol; sodium tetrahydroborate; at 25 ℃; Inert atmosphere;

DOI:10.1002/anie.201909919

Reference yield: 97.0%

quinolin-2-ylmethyl benzoate (61831-29-6) → quinolin-2-ylmethanol (1780-17-2)

Guidance literature:

With sodium methylate; In methanol; at 20 ℃; for 12h;

DOI:10.1055/s-2008-1032084

upstream raw materials:

quinoline 2-carbaldehyde

2-Chloromethylquinoline

quinoline-2-carboxylic acid methyl ester

ethyl quinoline-2-carboxylate

Downstream raw materials:

quinolin-2-ylmethyl benzoate

quinoline 2-carbaldehyde

2-Chloromethylquinoline

phenyl-carbamic acid-[2]quinolylmethyl ester

Refernces

• 1、 GRAEF,CANNON. "SYNTHESIS AND BIOLOGICAL ACTIVITIES OF CERTAIN SHORT-CHAIN MONO- AND". . p. 260 - 263. Retrieved 1965.
• 2、 Minisci, Francesco,Porta, Ombretta,Recupero, Francesco,Punta, Carlo,Gambarotti, Cristian,Pruna, Barbara,Pierini, Monica,Fontana, Francesca. "A new, convenient, highly selective free-radical hydroxymethylation of heteroaromatic bases by persulfate oxidation of ethylene glycol and glycerol, catalysed by AgNO3". . p. 874 - 876. Retrieved 2004.
• 3、 Yang, Yang,Wang, Haobing,Ma, Haiyan. "Unprecedented Reaction Pathway of Sterically Crowded Calcium Complexes: Sequential C?N Bond Cleavage Reactions Induced by C?H Bond Activations". . p. 239 - 247. Retrieved 2017.
• 4、 Xi, Zi-Wei,Yang, Lei,Wang, Dan-Yan,Feng, Chuan-Wei,Qin, Yufeng,Shen, Yong-Miao,Pu, Chaodan,Peng, Xiaogang. "Visible Light Induced Reduction and Pinacol Coupling of Aldehydes and Ketones Catalyzed by Core/Shell Quantum Dots". . p. 2474 - 2488. Retrieved 2021/02/05.
• 5、 Shantharjun, Bangarigalla,Vani, Damera,Unnava, Ramanjaneyulu,Sandeep, Mummadi,Reddy, Kallu Rajender. "Hydroxymethylation of quinolinesviairon promoted oxidative C-H functionalization: synthesis of arsindoline-A and its derivatives". . p. 645 - 652. Retrieved 2021/02/06.