phenylmethyl <6-<<(4-methylphenyl)sulfonyl>oxy>hexyl>carbamate

Base Information

• Chemical Name: phenylmethyl <6-<<(4-methylphenyl)sulfonyl>oxy>hexyl>carbamate
• CAS No.: 51224-12-5
• Molecular Formula: C₂₁H₂₇NO₅S
• Molecular Weight: 405.515
• Mol file: 51224-12-5.mol

Synonyms:phenylmethyl <6-<<(4-methylphenyl)sulfonyl>oxy>hexyl>carbamate

Chemical Property of phenylmethyl <6-<<(4-methylphenyl)sulfonyl>oxy>hexyl>carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of phenylmethyl <6-<<(4-methylphenyl)sulfonyl>oxy>hexyl>carbamate

There total 4 articles about phenylmethyl <6-<<(4-methylphenyl)sulfonyl>oxy>hexyl>carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.8%

N-benzyloxycarbonyl-6-amino-1-hexanol (17996-12-2) + p-toluenesulfonyl chloride (98-59-9) → phenylmethyl <6-<<(4-methylphenyl)sulfonyl>oxy>hexyl>carbamate (51224-12-5)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃;

Reference yield:

6-amino-1-hexanol (4048-33-3) → phenylmethyl <6-<<(4-methylphenyl)sulfonyl>oxy>hexyl>carbamate (51224-12-5)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaHCO₃

2: Py

With pyridine; sodium hydrogencarbonate;

DOI:10.1016/S0008-6215(00)86198-4

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → phenylmethyl <6-<<(4-methylphenyl)sulfonyl>oxy>hexyl>carbamate (51224-12-5)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap; sodium carbonate / water; tetrahydrofuran / 0 - 20 °C

2: triethylamine; dmap / dichloromethane / 0 - 20 °C

With dmap; sodium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; water;

upstream raw materials:

N-benzyloxycarbonyl-6-amino-1-hexanol

p-toluenesulfonyl chloride

6-amino-1-hexanol

benzyl chloroformate

Downstream raw materials:

N-[6-(benzyloxycarbonylamino)hexyl]-1,5-dideoxy-1,5-imino-D-galactitol

4,7-N,N-di-tert-butyloxycarbonyl-1-N-[6-(N-benzyloxycarbonyl)aminohexyl]-1,4,7-triazacyclononane

10-(6-benzyloxycarbonylamino-hexyl)-1,4,7,10-tetraaza-cyclododecane-1,4,7-tricarboxylic acid tri-tert-butyl ester

methyl N⁴-<6-<<(phenylmethoxy)carbonyl>amino>-1-hexyl>-N⁴-(2',3'-O-isopropylidene-5'-adenosyl)-2(R,S)-(trifluoroacetamido)-4-aminobutyrate