10-(6-benzyloxycarbonylamino-hexyl)-1,4,7,10-tetraaza-cyclododecane-1,4,7-tricarboxylic acid tri-tert-butyl ester

Base Information

• Chemical Name: 10-(6-benzyloxycarbonylamino-hexyl)-1,4,7,10-tetraaza-cyclododecane-1,4,7-tricarboxylic acid tri-tert-butyl ester
• CAS No.: 957829-63-9
• Molecular Formula: C₃₇H₆₃N₅O₈
• Molecular Weight: 705.936
• Mol file: 957829-63-9.mol

Synonyms:10-(6-benzyloxycarbonylamino-hexyl)-1,4,7,10-tetraaza-cyclododecane-1,4,7-tricarboxylic acid tri-tert-butyl ester

Chemical Property of 10-(6-benzyloxycarbonylamino-hexyl)-1,4,7,10-tetraaza-cyclododecane-1,4,7-tricarboxylic acid tri-tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 10-(6-benzyloxycarbonylamino-hexyl)-1,4,7,10-tetraaza-cyclododecane-1,4,7-tricarboxylic acid tri-tert-butyl ester

There total 8 articles about 10-(6-benzyloxycarbonylamino-hexyl)-1,4,7,10-tetraaza-cyclododecane-1,4,7-tricarboxylic acid tri-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

1,4,7-tris(tert-butyloxycarbonyl)-1,4,7,10-tetraazacyclododecane (175854-39-4) + 6-oxo-hexyl-carbamic acid benzyl ester (98648-05-6) → 10-(6-benzyloxycarbonylamino-hexyl)-1,4,7,10-tetraaza-cyclododecane-1,4,7-tricarboxylic acid tri-tert-butyl ester (957829-63-9)

Guidance literature:

With sodium tris(acetoxy)borohydride; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/jo071175v

Reference yield: 29.0%

N-benzyloxycarbonyl-6-bromo-1-hexylamine (116784-97-5) + 1,4,7-tris(tert-butyloxycarbonyl)-1,4,7,10-tetraazacyclododecane (175854-39-4) → 10-(6-benzyloxycarbonylamino-hexyl)-1,4,7,10-tetraaza-cyclododecane-1,4,7-tricarboxylic acid tri-tert-butyl ester (957829-63-9)

Guidance literature:

With potassium carbonate; In acetonitrile; for 96h; Heating;

DOI:10.1021/jo071175v

Reference yield: 15.0%

phenylmethyl <6-<<(4-methylphenyl)sulfonyl>oxy>hexyl>carbamate (51224-12-5) + 1,4,7-tris(tert-butyloxycarbonyl)-1,4,7,10-tetraazacyclododecane (175854-39-4) → 10-(6-benzyloxycarbonylamino-hexyl)-1,4,7,10-tetraaza-cyclododecane-1,4,7-tricarboxylic acid tri-tert-butyl ester (957829-63-9)

Guidance literature:

With potassium carbonate; In acetonitrile; Heating;

DOI:10.1021/jo071175v

upstream raw materials:

N-benzyloxycarbonyl-6-bromo-1-hexylamine

1,4,7-tris(tert-butyloxycarbonyl)-1,4,7,10-tetraazacyclododecane

6-oxo-hexyl-carbamic acid benzyl ester

phenylmethyl <6-<<(4-methylphenyl)sulfonyl>oxy>hexyl>carbamate