(E)-6-ethylidene-7-(2-oxo-2-phenylethyl)tetrahydropyrrolo[1,2-c]oxazol-3(1H)-one

Base Information

Chemical Name:(E)-6-ethylidene-7-(2-oxo-2-phenylethyl)tetrahydropyrrolo[1,2-c]oxazol-3(1H)-one
CAS No.:1310823-59-6
Molecular Formula:C₁₆H₁₇NO₃
Molecular Weight:271.316
Hs Code.:

Synonyms:(E)-6-ethylidene-7-(2-oxo-2-phenylethyl)tetrahydropyrrolo[1,2-c]oxazol-3(1H)-one

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Chemical Property of (E)-6-ethylidene-7-(2-oxo-2-phenylethyl)tetrahydropyrrolo[1,2-c]oxazol-3(1H)-one

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Technology Process of (E)-6-ethylidene-7-(2-oxo-2-phenylethyl)tetrahydropyrrolo[1,2-c]oxazol-3(1H)-one

There total 1 articles about (E)-6-ethylidene-7-(2-oxo-2-phenylethyl)tetrahydropyrrolo[1,2-c]oxazol-3(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: (E)-4-(3-oxo-3-phenylprop-1-en-1-yl)-3-(prop-2-yn-1-yl)oxazolidin-2-one

: 544-97-8
dimethyl zinc(II)

: 1310823-59-6
(E)-6-ethylidene-7-(2-oxo-2-phenylethyl)tetrahydropyrrolo[1,2-c]oxazol-3(1H)-one

Guidance literature:: dimethyl zinc(II); With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; In tetrahydrofuran; toluene; at 0 ℃; for 0.166667h; Inert atmosphere;

(E)-4-(3-oxo-3-phenylprop-1-en-1-yl)-3-(prop-2-yn-1-yl)oxazolidin-2-one; In tetrahydrofuran; toluene; at 0 ℃; Inert atmosphere;
DOI:10.1021/ol201133n

Reference yield: 64.0%

: 1310823-59-6
(E)-6-ethylidene-7-(2-oxo-2-phenylethyl)tetrahydropyrrolo[1,2-c]oxazol-3(1H)-one

: 1310823-61-0
7-(2-oxo-2-phenylethyl)dihydropyrrolo[1,2-c]oxazole-3,6(1H,5H)-dione

Guidance literature:: (E)-6-ethylidene-7-(2-oxo-2-phenylethyl)tetrahydropyrrolo[1,2-c]oxazol-3(1H)-one; With ozone; In dichloromethane; at -78 ℃; Inert atmosphere;

With triphenylphosphine; In dichloromethane; at -78 - 20 ℃; Inert atmosphere;
DOI:10.1021/ol201133n

Reference yield:

: 1310823-59-6
(E)-6-ethylidene-7-(2-oxo-2-phenylethyl)tetrahydropyrrolo[1,2-c]oxazol-3(1H)-one

: 1310823-63-2
2-phenyl-3b,4-dihydro-1H-pyrrolo[3',2':3,4]pyrrolo[1,2-c]oxazol-6(8H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: ozone / dichloromethane / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: ammonium acetate; acetic acid / tetrahydrofuran / 0.25 h / 170 °C / Inert atmosphere; Molecular sieve; Microwave irradiation

With ammonium acetate; ozone; acetic acid; In tetrahydrofuran; dichloromethane; 2.1: Paal-Knorr pyrrole synthesis;
DOI:10.1021/ol201133n