5-Methyl-2-phenyl-1H-benzoimidazole-4-carboxylic acid (2-dimethylamino-ethyl)-amide

Base Information

Chemical Name:5-Methyl-2-phenyl-1H-benzoimidazole-4-carboxylic acid (2-dimethylamino-ethyl)-amide
CAS No.:124340-69-8
Molecular Formula:C₁₉H₂₂N₄O
Molecular Weight:322.41
Hs Code.:

Synonyms:5-Methyl-2-phenyl-1H-benzoimidazole-4-carboxylic acid (2-dimethylamino-ethyl)-amide

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Chemical Property of 5-Methyl-2-phenyl-1H-benzoimidazole-4-carboxylic acid (2-dimethylamino-ethyl)-amide

Chemical Property:

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Technology Process of 5-Methyl-2-phenyl-1H-benzoimidazole-4-carboxylic acid (2-dimethylamino-ethyl)-amide

There total 6 articles about 5-Methyl-2-phenyl-1H-benzoimidazole-4-carboxylic acid (2-dimethylamino-ethyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 106976-22-1
5-bromo-4-methylisatin

: 124340-69-8
5-Methyl-2-phenyl-1H-benzoimidazole-4-carboxylic acid (2-dimethylamino-ethyl)-amide

Guidance literature:: Multi-step reaction with 7 steps

1: 27percent H₂O₂, 3percent aq. NaOH

2: 70 percent / AcOH / 0.17 h / 90 - 95 °C

3: 68 percent / fuming HNO₃ / 0.17 h / 5 °C

4: 97 percent / aq. NaOH / 5 h / 90 °C

5: H₂, aq. NaOH / Pd/C

6: cupric acetate, AcOH / H₂O; methanol / Heating

7: 1.) 1,1'-carbonyldiimidazole / 1.) DMF, 40 deg C, 5 min, 2.) 10 min

With sodium hydroxide; hydrogen; dihydrogen peroxide; nitric acid; copper diacetate; acetic acid; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In methanol; water;
DOI:10.1021/jm00164a054

Reference yield:

: 124341-06-6
6-amino-3-bromo-2-methylbenzoic acid

: 124340-69-8
5-Methyl-2-phenyl-1H-benzoimidazole-4-carboxylic acid (2-dimethylamino-ethyl)-amide

Guidance literature:: Multi-step reaction with 6 steps

1: 70 percent / AcOH / 0.17 h / 90 - 95 °C

2: 68 percent / fuming HNO₃ / 0.17 h / 5 °C

3: 97 percent / aq. NaOH / 5 h / 90 °C

4: H₂, aq. NaOH / Pd/C

5: cupric acetate, AcOH / H₂O; methanol / Heating

6: 1.) 1,1'-carbonyldiimidazole / 1.) DMF, 40 deg C, 5 min, 2.) 10 min

With sodium hydroxide; hydrogen; nitric acid; copper diacetate; acetic acid; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In methanol; water;
DOI:10.1021/jm00164a054

Reference yield:

: 124341-07-7
2-(acetylamino)-5-bromo-6-methylbenzoic acid

: 124340-69-8
5-Methyl-2-phenyl-1H-benzoimidazole-4-carboxylic acid (2-dimethylamino-ethyl)-amide

Guidance literature:: Multi-step reaction with 5 steps

1: 68 percent / fuming HNO₃ / 0.17 h / 5 °C

2: 97 percent / aq. NaOH / 5 h / 90 °C

3: H₂, aq. NaOH / Pd/C

4: cupric acetate, AcOH / H₂O; methanol / Heating

5: 1.) 1,1'-carbonyldiimidazole / 1.) DMF, 40 deg C, 5 min, 2.) 10 min

With sodium hydroxide; hydrogen; nitric acid; copper diacetate; acetic acid; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In methanol; water;
DOI:10.1021/jm00164a054