4,5-dihydro-5-<<4-<2-(1-methylethoxy)phenyl>-1-piperazinyl>methyl>-3-isoxazolemethanol

Base Information

Chemical Name:4,5-dihydro-5-<<4-<2-(1-methylethoxy)phenyl>-1-piperazinyl>methyl>-3-isoxazolemethanol
CAS No.:171855-18-8
Molecular Formula:C₁₈H₂₇N₃O₃
Molecular Weight:333.431
Hs Code.:

Synonyms:4,5-dihydro-5-<<4-<2-(1-methylethoxy)phenyl>-1-piperazinyl>methyl>-3-isoxazolemethanol

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Chemical Property of 4,5-dihydro-5-<<4-<2-(1-methylethoxy)phenyl>-1-piperazinyl>methyl>-3-isoxazolemethanol

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Technology Process of 4,5-dihydro-5-<<4-<2-(1-methylethoxy)phenyl>-1-piperazinyl>methyl>-3-isoxazolemethanol

There total 3 articles about 4,5-dihydro-5-<<4-<2-(1-methylethoxy)phenyl>-1-piperazinyl>methyl>-3-isoxazolemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 75233-61-3
2-(2-nitroethoxy)tetrahydro-2H-pyran

: 171855-38-2
1-allyl-4-(2-isopropoxy-phenyl)-piperazine

: 171855-18-8
4,5-dihydro-5-<<4-<2-(1-methylethoxy)phenyl>-1-piperazinyl>methyl>-3-isoxazolemethanol

Guidance literature:: With phenyl isocyanate; triethylamine; In toluene; a) 30 deg C, 12 h, b) 55 deg C, 92 h;
DOI:10.1021/jm00021a009

Reference yield:

: 1-(2-isopropoxy-phenyl)-4-[3-(tetrahydropyran-2-yloxymethyl)-4,5-dihydro-isoxazol-5-ylmethyl]-piperazine

: 171855-18-8
4,5-dihydro-5-<<4-<2-(1-methylethoxy)phenyl>-1-piperazinyl>methyl>-3-isoxazolemethanol

Guidance literature:: With hydrogenchloride; water; In diethyl ether;

Reference yield:

: 54013-91-1
2-(1-methylethoxy)phenyl-1-piperazine

: 171855-18-8
4,5-dihydro-5-<<4-<2-(1-methylethoxy)phenyl>-1-piperazinyl>methyl>-3-isoxazolemethanol

Guidance literature:: Multi-step reaction with 2 steps

1: 50.0 g / Et₃N / tetrahydrofuran / 18 h / Heating

2: 52 percent / PhNCO, Et₃N / toluene / a) 30 deg C, 12 h, b) 55 deg C, 92 h

With phenyl isocyanate; triethylamine; In tetrahydrofuran; toluene;
DOI:10.1021/jm00021a009