Technology Process of (2Z,4E)-ethyl 5-(2-((S)-2-(4-(benzyloxy)phenyl)-1-(cyclohexanecarboxamido)ethyl)-5-methylthiazol-4-yl)-2,4-dimethylpenta-2,4-dienoate
There total 10 articles about (2Z,4E)-ethyl 5-(2-((S)-2-(4-(benzyloxy)phenyl)-1-(cyclohexanecarboxamido)ethyl)-5-methylthiazol-4-yl)-2,4-dimethylpenta-2,4-dienoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / toluene; dimethyl sulfoxide / 2 h / 50 °C
2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 - 20 °C
2.2: 4 h / 20 °C
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C
4.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / toluene; dimethyl sulfoxide / 2 h / 50 °C
5.1: 18-crown-6 ether; potassium hexamethylsilazane / tetrahydrofuran / 1 h / -78 °C
5.2: 2 h / -78 °C
6.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C
7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Cooling with ice
With
lithium aluminium tetrahydride; 18-crown-6 ether; potassium hexamethylsilazane; sodium hydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
tetrahydrofuran; dichloromethane; dimethyl sulfoxide; toluene; mineral oil;
DOI:10.1016/j.ejmech.2013.09.017
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / toluene; dimethyl sulfoxide / 2 h / 50 °C
2.1: 18-crown-6 ether; potassium hexamethylsilazane / tetrahydrofuran / 1 h / -78 °C
2.2: 2 h / -78 °C
3.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C
4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Cooling with ice
With
18-crown-6 ether; potassium hexamethylsilazane; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
tetrahydrofuran; dichloromethane; dimethyl sulfoxide; toluene;
DOI:10.1016/j.ejmech.2013.09.017
