ethyl 2-((S)-3-(4-(benzyloxy)phenyl)-2-(tert-butoxycarbonylamino)propanamido)-3-oxobutanoate

Base Information

• Chemical Name: ethyl 2-((S)-3-(4-(benzyloxy)phenyl)-2-(tert-butoxycarbonylamino)propanamido)-3-oxobutanoate
• CAS No.: 1056754-02-9
• Molecular Formula: C₂₇H₃₄N₂O₇
• Molecular Weight: 498.576

Synonyms:ethyl 2-((S)-3-(4-(benzyloxy)phenyl)-2-(tert-butoxycarbonylamino)propanamido)-3-oxobutanoate

Chemical Property of ethyl 2-((S)-3-(4-(benzyloxy)phenyl)-2-(tert-butoxycarbonylamino)propanamido)-3-oxobutanoate

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Technology Process of ethyl 2-((S)-3-(4-(benzyloxy)phenyl)-2-(tert-butoxycarbonylamino)propanamido)-3-oxobutanoate

There total 2 articles about ethyl 2-((S)-3-(4-(benzyloxy)phenyl)-2-(tert-butoxycarbonylamino)propanamido)-3-oxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

O-benzyl-N-tert-butoxycarbonyl-L-tyrosine (2130-96-3,54784-43-9) + ethyl 2-amino-3-oxobutanoate hydrochloride (20207-16-3) → ethyl 2-((S)-3-(4-(benzyloxy)phenyl)-2-(tert-butoxycarbonylamino)propanamido)-3-oxobutanoate (1056754-02-9)

Guidance literature:

With pyridine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;

Reference yield: 47.0%

ethyl 2-amino-3-oxo-butanoate (65880-43-5) + O-benzyl-N-tert-butoxycarbonyl-L-tyrosine (2130-96-3,54784-43-9) → ethyl 2-((S)-3-(4-(benzyloxy)phenyl)-2-(tert-butoxycarbonylamino)propanamido)-3-oxobutanoate (1056754-02-9)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1016/j.ejmech.2013.09.017

Reference yield: 76.0%

ethyl 2-((S)-3-(4-(benzyloxy)phenyl)-2-(tert-butoxycarbonylamino)propanamido)-3-oxobutanoate (1056754-02-9) → (S)-ethyl 2-(2-(4-(benzyloxy)phenyl)-1-(tert-butoxycarbonylamino)ethyl)-5-methylthiazole-4-carboxylate (1056754-05-2)

Guidance literature:

With Lawessons reagent; In tetrahydrofuran; at 65 ℃; for 2h;

DOI:10.1016/j.ejmech.2013.09.017

upstream raw materials:

O-benzyl-N-tert-butoxycarbonyl-L-tyrosine

ethyl 2-amino-3-oxobutanoate hydrochloride

ethyl 2-amino-3-oxo-butanoate

Downstream raw materials:

(S)-ethyl 2-(2-(4-(benzyloxy)phenyl)-1-(tert-butoxycarbonylamino)ethyl)-5-methylthiazole-4-carboxylate

C₂₅H₃₀N₂O₄S

(S)-tert-butyl 2-(4-(benzyloxy)phenyl)-1-(4-formyl-5-methylthiazol-2-yl)ethylcarbamate

(S,E)-ethyl 3-(2-(2-(4-(benzyloxy)phenyl)-1-(tert-butoxycarbonylamino)ethyl)-5-methylthiazol-4-yl)-2-methylacrylate

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