8-(2-chlorophenyl)-2,2 dimethyl-8-(1,4,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-5-yl)-octanoic acid ethyl ester

Base Information

Chemical Name:8-(2-chlorophenyl)-2,2 dimethyl-8-(1,4,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-5-yl)-octanoic acid ethyl ester
CAS No.:1373491-83-8
Molecular Formula:C₂₅H₃₅ClN₂O₂
Molecular Weight:431.018
Hs Code.:

Synonyms:8-(2-chlorophenyl)-2,2 dimethyl-8-(1,4,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-5-yl)-octanoic acid ethyl ester

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Chemical Property of 8-(2-chlorophenyl)-2,2 dimethyl-8-(1,4,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-5-yl)-octanoic acid ethyl ester

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Technology Process of 8-(2-chlorophenyl)-2,2 dimethyl-8-(1,4,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-5-yl)-octanoic acid ethyl ester

There total 6 articles about 8-(2-chlorophenyl)-2,2 dimethyl-8-(1,4,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-5-yl)-octanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.9%

: 1373492-30-8
5-(1-(2-chlorophenyl)-7-ethoxycarbonyl-7-methyloctyl)-4,5,6,7-tetrahydropyrrolo[3,2-c]pyridine-1-carboxylic acid tert-butyl ester

: 1373491-83-8
8-(2-chlorophenyl)-2,2 dimethyl-8-(1,4,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-5-yl)-octanoic acid ethyl ester

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 1h; Inert atmosphere;

Reference yield:

: 123469-92-1
ethyl-2,2-dimethyl-7-bromoheptanoate

: 1373491-83-8
8-(2-chlorophenyl)-2,2 dimethyl-8-(1,4,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-5-yl)-octanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: toluene / 24 h / 122 °C

2: sodium hydroxide / dichloromethane

3: hydrogen bromide; acetic acid / 8 h / 15 °C

4: acetonitrile / 52 h / 45 °C

5: ethanol; sodium tetrahydroborate / 1 h / 20 °C

6: trifluoroacetic acid / dichloromethane / 1 h / Inert atmosphere

With sodium tetrahydroborate; ethanol; hydrogen bromide; acetic acid; trifluoroacetic acid; sodium hydroxide; In dichloromethane; toluene; acetonitrile;

Reference yield:

: 148760-75-2
tert-butyl 1H-pyrrolo[3,2-c]pyridine-1-carboxylate

: 1373491-83-8
8-(2-chlorophenyl)-2,2 dimethyl-8-(1,4,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-5-yl)-octanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: acetonitrile / 52 h / 45 °C

2: ethanol; sodium tetrahydroborate / 1 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 1 h / Inert atmosphere

With sodium tetrahydroborate; ethanol; trifluoroacetic acid; In dichloromethane; acetonitrile;