Technology Process of 4-((5-iodo-2-methylthiophen-3-yl)methyl)phenol
There total 6 articles about 4-((5-iodo-2-methylthiophen-3-yl)methyl)phenol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
copper(l) iodide; sodium iodide; N,N`-dimethylethylenediamine;
In
1,4-dioxane;
at 120 ℃;
for 18h;
Inert atmosphere;
DOI:10.1016/j.bmc.2011.08.014
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: acetic acid; pyridinium hydrobromide perbromide / 4 h / 40 °C / Inert atmosphere
2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C / Inert atmosphere
3.1: aluminum (III) chloride / dichloromethane / 17 h / 0 - 20 °C / Inert atmosphere
4.1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane; acetonitrile / 15 h / 0 - 20 °C / Inert atmosphere
5.1: boron tribromide / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere
5.2: 0 °C
6.1: copper(l) iodide; sodium iodide; N,N`-dimethylethylenediamine / 1,4-dioxane / 18 h / 120 °C / Inert atmosphere
With
triethylsilane; aluminum (III) chloride; copper(l) iodide; oxalyl dichloride; boron trifluoride diethyl etherate; boron tribromide; acetic acid; pyridinium hydrobromide perbromide; N,N-dimethyl-formamide; sodium iodide; N,N`-dimethylethylenediamine;
In
1,4-dioxane; dichloromethane; acetonitrile;
3.1: Friedel-Crafts acylation;
DOI:10.1016/j.bmc.2011.08.014
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C / Inert atmosphere
2.1: aluminum (III) chloride / dichloromethane / 17 h / 0 - 20 °C / Inert atmosphere
3.1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane; acetonitrile / 15 h / 0 - 20 °C / Inert atmosphere
4.1: boron tribromide / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere
4.2: 0 °C
5.1: copper(l) iodide; sodium iodide; N,N`-dimethylethylenediamine / 1,4-dioxane / 18 h / 120 °C / Inert atmosphere
With
triethylsilane; aluminum (III) chloride; copper(l) iodide; oxalyl dichloride; boron trifluoride diethyl etherate; boron tribromide; N,N-dimethyl-formamide; sodium iodide; N,N`-dimethylethylenediamine;
In
1,4-dioxane; dichloromethane; acetonitrile;
2.1: Friedel-Crafts acylation;
DOI:10.1016/j.bmc.2011.08.014
