4-N-benzoyl-5'-O-(4,4'-dimethoxytrityl)-5-methyl-2'-O,4'-C-(methylenoxymethylene)cytidine

Base Information

Chemical Name:4-N-benzoyl-5'-O-(4,4'-dimethoxytrityl)-5-methyl-2'-O,4'-C-(methylenoxymethylene)cytidine
CAS No.:877823-52-4
Molecular Formula:C₄₀H₃₉N₃O₉
Molecular Weight:705.764
Hs Code.:

Synonyms:4-N-benzoyl-5'-O-(4,4'-dimethoxytrityl)-5-methyl-2'-O,4'-C-(methylenoxymethylene)cytidine

Suppliers and Price of 4-N-benzoyl-5'-O-(4,4'-dimethoxytrityl)-5-methyl-2'-O,4'-C-(methylenoxymethylene)cytidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-N-benzoyl-5'-O-(4,4'-dimethoxytrityl)-5-methyl-2'-O,4'-C-(methylenoxymethylene)cytidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-N-benzoyl-5'-O-(4,4'-dimethoxytrityl)-5-methyl-2'-O,4'-C-(methylenoxymethylene)cytidine

There total 11 articles about 4-N-benzoyl-5'-O-(4,4'-dimethoxytrityl)-5-methyl-2'-O,4'-C-(methylenoxymethylene)cytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 877823-51-3
4-N-benzoyl-5-methyl-2'-O,4'-C-(methylenoxymethylene)cytidine

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 877823-52-4
4-N-benzoyl-5'-O-(4,4'-dimethoxytrityl)-5-methyl-2'-O,4'-C-(methylenoxymethylene)cytidine

Guidance literature:: With pyridine; at 20 ℃; for 12h;
DOI:10.1016/j.bmc.2005.09.020

Reference yield:

: 877823-50-2
4-N-benzoyl-3'-O-benzyl-5-methyl-2'-O,4'-C-(methylenoxymethylene)cytidine

: 877823-52-4
4-N-benzoyl-5'-O-(4,4'-dimethoxytrityl)-5-methyl-2'-O,4'-C-(methylenoxymethylene)cytidine

Guidance literature:: Multi-step reaction with 2 steps

1: 68 percent / cyclohexene / Pd/C / tetrahydrofuran / 4 h / Heating

2: 93 percent / pyridine / 12 h / 20 °C

With pyridine; cyclohexene; palladium on activated charcoal; In tetrahydrofuran;
DOI:10.1016/j.bmc.2005.09.020

Reference yield:

: 583829-86-1
4-C-acetoxymethyl-1,2-di-O-acetyl-3-O-benzyl-5-O-tert-butyldiphenylsilyl-D-erythro-pentofuranose

: 877823-52-4
4-N-benzoyl-5'-O-(4,4'-dimethoxytrityl)-5-methyl-2'-O,4'-C-(methylenoxymethylene)cytidine

Guidance literature:: Multi-step reaction with 9 steps

1: 93 percent / N,O-bis(trimethylsilyl)acetamide; TMSOTf / acetonitrile / 1 h / Heating

2: 90 percent / K₂CO₃ / methanol / 4 h / 20 °C

3: 81 percent / TsOH*H₂O / 1,2-dichloro-ethane / 3 h / Heating

4: POCl₃; triethylamine / acetonitrile / 5.5 h / 20 °C

5: 246 mg / aq. NH₃ / dioxane / 2 h / 20 °C

6: 87 percent / pyridine / 3.5 h / 20 °C

7: 97 percent / TBAF / tetrahydrofuran / 10 h / 20 °C

8: 68 percent / cyclohexene / Pd/C / tetrahydrofuran / 4 h / Heating

9: 93 percent / pyridine / 12 h / 20 °C

With pyridine; ammonium hydroxide; N,O-bis-(trimethylsilyl)-acetamide; trimethylsilyl trifluoromethanesulfonate; tetrabutyl ammonium fluoride; potassium carbonate; toluene-4-sulfonic acid; triethylamine; cyclohexene; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dichloro-ethane; acetonitrile; 1: Vorbrueggen reaction;
DOI:10.1016/j.bmc.2005.09.020