C₃₁H₄₅N₅O₄S

Base Information

• Chemical Name: C₃₁H₄₅N₅O₄S
• CAS No.: 1357007-79-4
• Molecular Formula: C₃₁H₄₅N₅O₄S
• Molecular Weight: 583.795
• Mol file: 1357007-79-4.mol

Synonyms:C₃₁H₄₅N₅O₄S

Chemical Property of C₃₁H₄₅N₅O₄S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₁H₄₅N₅O₄S

There total 20 articles about C₃₁H₄₅N₅O₄S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 4.0%

C31H47N5O5S (1357008-67-3) → C31H45N5O4S (1357007-79-4)

Guidance literature:

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; HATU; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one; In dichloromethane; acetonitrile; for 12h;

DOI:10.1016/j.tet.2011.11.089

Reference yield:

N-tert-butoxycarbonyl-L-leucine (13139-15-6,53296-34-7) → C31H45N5O4S (1357007-79-4)

Guidance literature:

Multi-step reaction with 8 steps

1.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

2.1: dihydrogen peroxide; lithium hydroxide / methanol / 0 °C

2.2: pH 1

3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

4.1: dihydrogen peroxide; lithium hydroxide / methanol / 0 °C

4.2: pH 1

5.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / dichloromethane / 1.5 h / 20 °C / Inert atmosphere

6.1: dihydrogen peroxide; lithium hydroxide / methanol / 3 h / 20 °C

6.2: pH 1

7.1: methoxybenzene; trifluoroacetic acid / dichloromethane / 0.67 h

8.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; HATU; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one / dichloromethane; acetonitrile / 12 h

With dihydrogen peroxide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; methoxybenzene; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one; lithium hydroxide; In methanol; dichloromethane; acetonitrile;

DOI:10.1016/j.tet.2011.11.089

Reference yield:

C38H59N5O7S (1357008-06-0) → C31H45N5O4S (1357007-79-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: dihydrogen peroxide; lithium hydroxide / methanol / 3 h / 20 °C

1.2: pH 1

2.1: methoxybenzene; trifluoroacetic acid / dichloromethane / 0.67 h

3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; HATU; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one / dichloromethane; acetonitrile / 12 h

With dihydrogen peroxide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; methoxybenzene; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one; lithium hydroxide; In methanol; dichloromethane; acetonitrile;

DOI:10.1016/j.tet.2011.11.089

upstream raw materials:

methyl (S)-2-[(S)-2-(tert-butoxycarbonylamino)-N-methyl-3-phenylpropanamido]-4-methylpentanoate

H-Phe-NMe-Leu-OMe

C₃₈H₅₉N₅O₇S

C₃₆H₅₅N₅O₇S

Refernces