2S-((+)-α-methoxy-α-trifluoromethylphenylacetylamino)-3-phenylpropionic acid, methyl ester

Base Information

Chemical Name:2S-((+)-α-methoxy-α-trifluoromethylphenylacetylamino)-3-phenylpropionic acid, methyl ester
CAS No.:70363-10-9
Molecular Formula:C₂₀H₂₀F₃NO₄
Molecular Weight:395.378
Hs Code.:

Synonyms:2S-((+)-α-methoxy-α-trifluoromethylphenylacetylamino)-3-phenylpropionic acid, methyl ester

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Chemical Property of 2S-((+)-α-methoxy-α-trifluoromethylphenylacetylamino)-3-phenylpropionic acid, methyl ester

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Technology Process of 2S-((+)-α-methoxy-α-trifluoromethylphenylacetylamino)-3-phenylpropionic acid, methyl ester

There total 7 articles about 2S-((+)-α-methoxy-α-trifluoromethylphenylacetylamino)-3-phenylpropionic acid, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 39637-99-5,20445-33-4
(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride

: 7524-50-7
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

: 67472-38-2,70363-10-9,70363-28-9,126216-26-0,128360-01-0
2R-((-)-α-methoxy-α-trifluoromethylphenylacetylamino)-3-phenylpropionoc acid, methyl ester

Guidance literature:: DOI:10.1016/S0040-4020(01)86058-0

Reference yield: 94.0%

: 20445-33-4,39637-99-5
(R)-methoxytrifluoromethylphenylacetyl chloride

: 7524-50-7
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

: 70363-10-9
2S-((+)-α-methoxy-α-trifluoromethylphenylacetylamino)-3-phenylpropionic acid, methyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 25 ℃; for 2h;
DOI:10.1016/S0040-4020(01)86058-0

Reference yield: 91.4%

: 2577-90-4
methyl (2S)-2-amino-3-phenylpropanoate

: 39637-99-5,20445-33-4
(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride

: 70363-10-9
2S-((+)-α-methoxy-α-trifluoromethylphenylacetylamino)-3-phenylpropionic acid, methyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 25 - 28 ℃; for 2h; Schlenk technique; Inert atmosphere;
DOI:10.1039/c5cc04594k