(3-benzyloxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-[4-(2-ethoxy-ethoxy)-phenyl]-phosphinic acid ethyl ester

Base Information

Chemical Name:(3-benzyloxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-[4-(2-ethoxy-ethoxy)-phenyl]-phosphinic acid ethyl ester
CAS No.:362476-94-6
Molecular Formula:C₂₉H₃₅N₂O₆P
Molecular Weight:538.58
Hs Code.:

(3-benzyloxycarbamoyl-3,4-dihydro-1<i>H</i>-isoquinolin-2-yl)-[4-(2-ethoxy-ethoxy)-phenyl]-phosphinic acid ethyl ester

Synonyms:(3-benzyloxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-[4-(2-ethoxy-ethoxy)-phenyl]-phosphinic acid ethyl ester

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Chemical Property of (3-benzyloxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-[4-(2-ethoxy-ethoxy)-phenyl]-phosphinic acid ethyl ester

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Technology Process of (3-benzyloxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-[4-(2-ethoxy-ethoxy)-phenyl]-phosphinic acid ethyl ester

There total 7 articles about (3-benzyloxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-[4-(2-ethoxy-ethoxy)-phenyl]-phosphinic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 362477-50-7
C₁₂H₁₈ClO₄P

: 404001-44-1
(3R)-N-benzyloxy-1,2,3,4-tetrahydroisoquinoline-3-hydroxamide

: 362476-94-6
(3-benzyloxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-[4-(2-ethoxy-ethoxy)-phenyl]-phosphinic acid ethyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;
DOI:10.1016/S0960-894X(01)00796-X

Reference yield:

: 362477-41-6
diethyl 4-(2-ethoxyethoxy)phenylphosphonate

: 362476-94-6
(3-benzyloxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-[4-(2-ethoxy-ethoxy)-phenyl]-phosphinic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: KOH

2: SOCl₃; DMF / Heating

3: i-Pr₂NEt / tetrahydrofuran

With potassium hydroxide; thionyl chloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran;
DOI:10.1016/S0960-894X(01)00796-X

Reference yield:

: 41220-48-8
(3R)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride

: 362476-94-6
(3-benzyloxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-[4-(2-ethoxy-ethoxy)-phenyl]-phosphinic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 61 percent / aq. sodium carbonate / dioxane / 20 °C

2: 41 percent / WSC; HOBt; triethylamine / dimethylformamide / 20 °C

3: 4.6 g / 4N HCl / ethyl acetate / 2 h / 20 °C

4: diisopropylethylamine / CH₂Cl₂ / 20 °C

With hydrogenchloride; sodium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm0103211