D-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID HYDROCHLORIDE

Base Information

Chemical Name:D-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID HYDROCHLORIDE
CAS No.:41220-48-8
Molecular Formula:C10H11 N O2 . Cl H
Molecular Weight:213.66
Hs Code.:29334990
Mol file:41220-48-8.mol

Synonyms:3-Isoquinolinecarboxylicacid, 1,2,3,4-tetrahydro-, hydrochloride, (3R)- (9CI); 3-Isoquinolinecarboxylicacid, 1,2,3,4-tetrahydro-, hydrochloride, (R)-;(3R)-1,2,3,4-Tetrahydroisoquinole-3-carboxylic acid hydrochloride

Suppliers and Price of D-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID HYDROCHLORIDE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 11 raw suppliers

Chemical Property of D-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID HYDROCHLORIDE

Chemical Property:

Melting Point:300 °C
PSA：49.33000
LogP:1.91630

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Safety Statements: 24/25

MSDS Files:

Useful:

Technology Process of D-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID HYDROCHLORIDE

There total 2 articles about D-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 673-06-3,25191-15-5,658-69-5,67675-33-6
D-(R)-phenylalanine

: 41220-48-8
(3R)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride

Guidance literature:: With hydrogenchloride; In water; at 95 - 100 ℃; for 4h;
DOI:10.1248/cpb.31.312

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 673-06-3,25191-15-5,658-69-5,67675-33-6
D-(R)-phenylalanine

: 41220-48-8
(3R)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride

: 77497-95-1
(3S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride

Guidance literature:: With hydrogenchloride; In water; at 95 ℃; for 7h;
DOI:10.1021/acs.jmedchem.7b01420

Reference yield:

: 41220-48-8
(3R)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride

: (S)-((R)-3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-(4-methoxy-phenyl)-phosphinic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 61 percent / aq. sodium carbonate / dioxane / 20 °C

2: 41 percent / WSC; HOBt; triethylamine / dimethylformamide / 20 °C

3: 4.6 g / 4N HCl / ethyl acetate / 2 h / 20 °C

4: pyridine / 0.25 h / 20 °C

5: pyridine / 1 h / 20 °C

6: 34 percent / H₂ / 10percent Pd/C / ethanol / 3 h / 20 °C

With pyridine; hydrogenchloride; hydrogen; sodium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; 10percent Pd/C; In 1,4-dioxane; ethanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm0103211