(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-[2-(bromomethyl)-5-(trifluoromethyl)benzyl]-4-methyl-1,3-oxazolidin-2-one

Base Information

Chemical Name:(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-[2-(bromomethyl)-5-(trifluoromethyl)benzyl]-4-methyl-1,3-oxazolidin-2-one
CAS No.:944158-27-4
Molecular Formula:C₂₁H₁₅BrF₉NO₂
Molecular Weight:564.245
Hs Code.:

Synonyms:(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-[2-(bromomethyl)-5-(trifluoromethyl)benzyl]-4-methyl-1,3-oxazolidin-2-one

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Chemical Property of (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-[2-(bromomethyl)-5-(trifluoromethyl)benzyl]-4-methyl-1,3-oxazolidin-2-one

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Technology Process of (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-[2-(bromomethyl)-5-(trifluoromethyl)benzyl]-4-methyl-1,3-oxazolidin-2-one

There total 11 articles about (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-[2-(bromomethyl)-5-(trifluoromethyl)benzyl]-4-methyl-1,3-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 943917-29-1
(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-[2-(hydroxymethyl)-5-(trifluoromethyl)benzyl]-4-methyl-1,3-oxazolidin-2-one

: 944158-27-4
(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-[2-(bromomethyl)-5-(trifluoromethyl)benzyl]-4-methyl-1,3-oxazolidin-2-one

Guidance literature:: With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 0 - 20 ℃; for 1.5h;

Reference yield:

: 702641-04-1
2-iodo-5-(trifluoromethyl)benzoic acid

: 944158-27-4
(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-[2-(bromomethyl)-5-(trifluoromethyl)benzyl]-4-methyl-1,3-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: borane-THF / tetrahydrofuran / 1.5 h / 0 °C / Heating / reflux

2: carbon tetrabromide; triphenylphosphine / dichloromethane / 62 h / 0 - 20 °C

3: sodium hydride / 18 h / 20 °C

4: N,N-dimethyl-formamide / 14 h / 100 °C

5: formic acid / platinum(IV) oxide / water / 22 h / 60 °C

6: sodium tetrahydroborate / methanol / 0.5 h / 0 °C

7: carbon tetrabromide; triphenylphosphine / dichloromethane / 1.5 h / 0 - 20 °C

With sodium tetrahydroborate; formic acid; borane-THF; carbon tetrabromide; sodium hydride; triphenylphosphine; platinum(IV) oxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 702641-05-2
[2-iodo-5-(trifluoromethyl)phenyl]methanol

: 944158-27-4
(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-[2-(bromomethyl)-5-(trifluoromethyl)benzyl]-4-methyl-1,3-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: carbon tetrabromide; triphenylphosphine / dichloromethane / 62 h / 0 - 20 °C

2: sodium hydride / 18 h / 20 °C

3: N,N-dimethyl-formamide / 14 h / 100 °C

4: formic acid / platinum(IV) oxide / water / 22 h / 60 °C

5: sodium tetrahydroborate / methanol / 0.5 h / 0 °C

6: carbon tetrabromide; triphenylphosphine / dichloromethane / 1.5 h / 0 - 20 °C

With sodium tetrahydroborate; formic acid; carbon tetrabromide; sodium hydride; triphenylphosphine; platinum(IV) oxide; In methanol; dichloromethane; water; N,N-dimethyl-formamide;