N-(9-fluorenylmethoxycarbonyl)-O-[(α,α-dimethyl-4-nitrobenzyl)dimethylsilyl]-L-serine allyl ester

Base Information

• Chemical Name: N-(9-fluorenylmethoxycarbonyl)-O-[(α,α-dimethyl-4-nitrobenzyl)dimethylsilyl]-L-serine allyl ester
• CAS No.: 221325-37-7
• Molecular Formula: C₃₂H₃₆N₂O₇Si
• Molecular Weight: 588.733
• Mol file: 221325-37-7.mol

Synonyms:N-(9-fluorenylmethoxycarbonyl)-O-[(α,α-dimethyl-4-nitrobenzyl)dimethylsilyl]-L-serine allyl ester

Chemical Property of N-(9-fluorenylmethoxycarbonyl)-O-[(α,α-dimethyl-4-nitrobenzyl)dimethylsilyl]-L-serine allyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(9-fluorenylmethoxycarbonyl)-O-[(α,α-dimethyl-4-nitrobenzyl)dimethylsilyl]-L-serine allyl ester

There total 5 articles about N-(9-fluorenylmethoxycarbonyl)-O-[(α,α-dimethyl-4-nitrobenzyl)dimethylsilyl]-L-serine allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-(9-fluorenylmethoxycarbonyl)-L-serine allyl ester (136497-85-3) + chloro(α,α-dimethyl-4-nitrobenzyl)dimethylsilane (221325-35-5) → N-(9-fluorenylmethoxycarbonyl)-O-[(α,α-dimethyl-4-nitrobenzyl)dimethylsilyl]-L-serine allyl ester (221325-37-7)

Guidance literature:

With 4-methyl-morpholine; sodium iodide; In N,N-dimethyl-formamide; Ambient temperature;

DOI:10.1016/S0040-4039(98)02390-9

Reference yield: 16.0%

N-(9-fluorenylmethoxycarbonyl)-L-serine allyl ester (136497-85-3) + chloro(α,α-dimethyl-4-nitrobenzyl)dimethylsilane (221325-35-5) → N-(9-fluorenylmethoxycarbonyl)-O-[(α,α-dimethyl-4-nitrobenzyl)dimethylsilyl]-L-serine allyl ester (221325-37-7) + C34H42N2O8Si2

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

DOI:10.1016/S0040-4020(99)00649-3

Reference yield:

(α,α-dimethyl-4-nitrobenzyl)dimethylsilanol (221325-34-4) → N-(9-fluorenylmethoxycarbonyl)-O-[(α,α-dimethyl-4-nitrobenzyl)dimethylsilyl]-L-serine allyl ester (221325-37-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / oxalyl chloride; DMF / CH₂Cl₂ / 0 - 20 °C

2: 97 percent / N-methylmorpholine; NaI / dimethylformamide / 0.58 h / 20 °C

With 4-methyl-morpholine; oxalyl dichloride; N,N-dimethyl-formamide; sodium iodide; In dichloromethane; N,N-dimethyl-formamide; 1: Substitution / 2: Substitution;

DOI:10.1016/S0040-4020(99)00649-3

upstream raw materials:

N-(9-fluorenylmethoxycarbonyl)-L-serine allyl ester

chloro(α,α-dimethyl-4-nitrobenzyl)dimethylsilane

chloro(α,α-dimethylbenzyl)dimethylsilane

(α,α-dimethylbenzyl)dimethylsilanol

Downstream raw materials:

N-(9-fluorenylmethoxycarbonyl)-O-[(4-amino-α,α-dimethylbenzyl)dimethylsilyl]-L-serine allyl ester

N-(9-fluorenylmethoxycarbonyl)-O-[(α,α-dimethyl-4-succin-monoamidobenzyl)dimethylsilyl]-L-serine allyl ester