4-Methyl-1,4'-bipiperidine

Base Information

• Chemical Name: 4-Methyl-1,4'-bipiperidine
• CAS No.: 116797-02-5
• Molecular Formula: C11H22N2
• Molecular Weight: 182.309
• Hs Code.: 2933399090
• European Community (EC) Number: 673-617-1
• DSSTox Substance ID: DTXSID80355282
• Wikidata: Q82134074
• Mol file: 116797-02-5.mol

Synonyms:116797-02-5;4-methyl-1,4'-bipiperidine;4-Methyl-[1,4']bipiperidinyl;4-methyl-1-piperidin-4-ylpiperidine;4-(4-methyl-piperidin-1-yl)-piperidine;4-(4-methylpiperidin-1-yl)piperidine;4-(4-methylpiperidino)piperidine;1,4'-Bipiperidine, 4-methyl-;MFCD03274731;1,4'-Bipiperidine,4-methyl-;BAS 04918781;4-methyl-1-(piperidin-4-yl)piperidine;Oprea1_477592;Oprea1_821379;SCHEMBL310092;DTXSID80355282;AKOS000181127;AM85302;PS-3231;SB41120;4-methyl-1-(3,4,5,6-tetrahydro-2H-pyridin-4-yl)-3,4,5,6-tetrahydro-2H-pyridine;4-METHYL-[1,4/']BIPIPERIDINYL;BB 0254787;CS-0196527;FT-0654829;F17136;EN300-7409268;A803671;4-(4-methyl-piperidin-1-yl)-piperidine, AldrichCPR

Chemical Property of 4-Methyl-1,4'-bipiperidine

Chemical Property:

• Melting Point: 40-42 °C
• Boiling Point: 254.1 °C at 760 mmHg
• Flash Point: 91.3 °C
• PSA: 15.27000
• Density: 0.941 g/cm³
• LogP: 1.73700
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 182.178298710
• Heavy Atom Count: 13
• Complexity: 144

Purity/Quality:

97% ^*data from raw suppliers

4-Methyl-1,4''-bipiperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22-41

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1CCN(CC1)C2CCNCC2

Technology Process of 4-Methyl-1,4'-bipiperidine

There total 5 articles about 4-Methyl-1,4'-bipiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

N-[(benzyloxy)carbonyl]-4-methyl-[1,4']bipiperidine → 4-(4-methylpiperidin-1-yl)piperidine (116797-02-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 2h;

DOI:10.1002/anie.200502991

Reference yield:

benzyl 4-oxo-1-piperidinecarboxylate (19099-93-5) → 4-(4-methylpiperidin-1-yl)piperidine (116797-02-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 51 percent / NaBH(OAc)3 / 1,2-dichloro-ethane / 20 °C

2: 64 percent / H₂ / Pd/C / ethanol / 2 h / 20 °C

With hydrogen; sodium tris(acetoxy)borohydride; palladium on activated charcoal; In ethanol; 1,2-dichloro-ethane;

DOI:10.1002/anie.200502991

Reference yield:

4-methylpiperidin (626-58-4) → 4-(4-methylpiperidin-1-yl)piperidine (116797-02-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 51 percent / NaBH(OAc)3 / 1,2-dichloro-ethane / 20 °C

2: 64 percent / H₂ / Pd/C / ethanol / 2 h / 20 °C

With hydrogen; sodium tris(acetoxy)borohydride; palladium on activated charcoal; In ethanol; 1,2-dichloro-ethane;

DOI:10.1002/anie.200502991

upstream raw materials:

4-methylpiperidin

benzyl 4-oxo-1-piperidinecarboxylate

piperidine-4,4-diol hydrochloride

Downstream raw materials:

4-chloro-8-(2,6-difluorophenyl)-2-(4-methyl-1,4'-bipiperidin-1'-yl)-pyrido[2,3-d]pyrimidin-7(8H)-one

N-(3-chlorophenyl)-3-(4-methyl-1,4'-bipiperidin-1'-yl)-5-(trifluoromethyl)benzamide