methyl 3-[{[2-fluoro-4-(trifluoromethyl)phenyl]carbonyl}-(1-methylethyl)amino]-5-(4-pyrazolo[1,5-a]pyrimidin-2-ylphenyl)-2-thiophenecarboxylate

Base Information

Chemical Name:methyl 3-[{[2-fluoro-4-(trifluoromethyl)phenyl]carbonyl}-(1-methylethyl)amino]-5-(4-pyrazolo[1,5-a]pyrimidin-2-ylphenyl)-2-thiophenecarboxylate
CAS No.:1019338-22-7
Molecular Formula:C₂₉H₂₂F₄N₄O₃S
Molecular Weight:582.578
Hs Code.:

methyl 3-[{[2-fluoro-4-(trifluoromethyl)phenyl]carbonyl}-(1-methylethyl)amino]-5-(4-pyrazolo[1,5-a]pyrimidin-2-ylphenyl)-2-thiophenecarboxylate

Synonyms:methyl 3-[{[2-fluoro-4-(trifluoromethyl)phenyl]carbonyl}-(1-methylethyl)amino]-5-(4-pyrazolo[1,5-a]pyrimidin-2-ylphenyl)-2-thiophenecarboxylate

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Chemical Property of methyl 3-[{[2-fluoro-4-(trifluoromethyl)phenyl]carbonyl}-(1-methylethyl)amino]-5-(4-pyrazolo[1,5-a]pyrimidin-2-ylphenyl)-2-thiophenecarboxylate

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Technology Process of methyl 3-[{[2-fluoro-4-(trifluoromethyl)phenyl]carbonyl}-(1-methylethyl)amino]-5-(4-pyrazolo[1,5-a]pyrimidin-2-ylphenyl)-2-thiophenecarboxylate

There total 1 articles about methyl 3-[{[2-fluoro-4-(trifluoromethyl)phenyl]carbonyl}-(1-methylethyl)amino]-5-(4-pyrazolo[1,5-a]pyrimidin-2-ylphenyl)-2-thiophenecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 942590-37-6
methyl 3-[(1-methylethyl)amino]-5-(4-pyrazolo[1,5-a]pyrimidin-2-ylphenyl)-2-thiophenecarboxylate

: 126917-10-0
2-fluoro-4-(trifluoromethyl)benzoyl chloride

: 1019338-22-7
methyl 3-[{[2-fluoro-4-(trifluoromethyl)phenyl]carbonyl}-(1-methylethyl)amino]-5-(4-pyrazolo[1,5-a]pyrimidin-2-ylphenyl)-2-thiophenecarboxylate

Guidance literature:: methyl 3-[(1-methylethyl)amino]-5-(4-pyrazolo[1,5-a]pyrimidin-2-ylphenyl)-2-thiophenecarboxylate; 2-fluoro-4-(trifluoromethyl)benzoyl chloride; With triphenylphosphine; In dichloromethane; at 45 ℃;

With sodium hydrogencarbonate; In dichloromethane; water; at 20 ℃; for 1h;

Reference yield:

: 1019338-22-7
methyl 3-[{[2-fluoro-4-(trifluoromethyl)phenyl]carbonyl}-(1-methylethyl)amino]-5-(4-pyrazolo[1,5-a]pyrimidin-2-ylphenyl)-2-thiophenecarboxylate

: 1019337-45-1
3-[{[2-fluoro-4-(trifluoromethyl)phenyl]carbonyl}-(1-methylethyl)amino]-5-(4-pyrazolo[1,5-a]pyrimidin-2-ylphenyl)-2-thiophenecarboxylic acid

Guidance literature:: methyl 3-[{[2-fluoro-4-(trifluoromethyl)phenyl]carbonyl}-(1-methylethyl)amino]-5-(4-pyrazolo[1,5-a]pyrimidin-2-ylphenyl)-2-thiophenecarboxylate; With sodium hydroxide; water; In tetrahydrofuran; methanol;

With hydrogenchloride; In tetrahydrofuran; methanol; dichloromethane; water; for 0.5h;